Potent In Vitro Antibacterial Activity of DS-8587, a Novel Broad-Spectrum Quinolone, against Acinetobacter baumannii

被引：19

作者：

Higuchi, Saito ^{[1
,2
]}

Onodera, Yoshikuni ^{[1
]}

Chiba, Megumi ^{[1
]}

Hoshino, Kazuki ^{[1
]}

Gotoh, Naomasa ^{[2
]}

机构：

[1] Daiichi Sankyo Co Ltd, Biol Res Labs, Tokyo, Japan

[2] Kyoto Pharmaceut Univ, Dept Microbiol & Infect Control Sci, Kyoto 607, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 04期

基金：

日本学术振兴会;

关键词：

RESISTANCE; EFFLUX; MECHANISMS; IDENTIFICATION; EMERGENCE; DC-159A; THREAT;

D O I：

10.1128/AAC.02374-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the in vitro activity of DS-8587, a novel fluoroquinolone, against Acinetobacter baumannii. The MICs of DS-8587 against clinical isolates and its inhibitory activity against target enzymes were superior to those of ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps than was that of ciprofloxacin and the frequency of single-step mutations with DS-8587 was lower than that with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.

引用

页码：1978 / 1981

页数：4

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