Intrathecal IgG synthesis:: marker of progression in multiple sclerosis patients

被引：39
作者：
Izquierdo, G
Angulo, S
Garcia-Moreno, JM
Gamero, MA
Navarro, G
Gata, JM
Ruiz-Peña, JL
Páramo, MD
机构：
[1] Hosp Univ Virgen Macarena, Serv Neurol, Seville 41009, Spain
[2] Hosp Univ Virgen Macarena, Serv Bioquim, Seville 41009, Spain
来源：
ACTA NEUROLOGICA SCANDINAVICA | 2002年 / 105卷 / 03期
关键词：
multiple sclerosis; cerebrospinal fluids; IgG intrathecal synthesis; prognosis;
D O I：
10.1034/j.1600-0404.2002.1o009.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We study the power of IgG synthesis value as a marker of disease activity in multiple sclerosis (MS). Material and methods Link index was calculated in 202 MS patients. Time between first, second and third attack and progression index (PI) were compared in patient with normal (NLI) high (HL) or very high Link index (VHLI). Results - Secondary progressive (SP) patients had a higher LI than relapsing-remitting (RR) and primary progressive (PP) courses (1.10 +/- 0.5 for SP vs 0.86 +/- 0.5 for RR and 0.81 +/- 0.5 for PP. P = 0.01 and 0.03, respectively). Having a HLI in MS RR and SP patients has no time effect in the development of the second and third attack. PI was higher in patients with VHIL (0.67 +/- 0.7) vs patients with NLI (0.42 +/- 0.4. P = 0.008) and with HLI (0.39 +/- 0.3, P = 0.001). Conclusions - This study confirmed that LI is a good marker of subsequent progression of MS.
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页码：158 / 163
页数：6
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