Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

被引:46
作者
Baugh, L. Ryan [1 ]
Day, Troy [2 ,3 ]
机构
[1] Duke Univ, Ctr Genom & Computat Biol, Dept Biol, Durham, NC 27706 USA
[2] Queens Univ, Dept Math, Dept Biol, Kingston, ON, Canada
[3] Queens Univ, Dept Stat, Dept Biol, Kingston, ON, Canada
关键词
DOUBLE-STRANDED-RNA; TRANSGENERATIONAL EPIGENETIC INHERITANCE; CELL LINEAGES; GERMLINE; INTERFERENCE; TRANSMISSION; INFORMATION; STARVATION; LONGEVITY;
D O I
10.7554/eLife.58498
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A rapidly growing body of literature in several organisms suggests that environmentally-induced adaptive changes in phenotype can be transmitted across multiple generations. Although within-generation plasticity has been well documented, multigenerational plasticity represents a significant departure from conventional evolutionary thought. Studies of C. elegans have been particularly influential because this species exhibits extensive phenotypic plasticity, it is often essentially isogenic, and it has well-documented molecular and cellular mechanisms through which nongenetic inheritance occurs. However, while experimentalists are eager to claim that nongenetic modes of inheritance characterized in this and other model systems enhance fitness, many biologists remain skeptical given the extraordinary nature of this claim. We establish three criteria to evaluate how compelling the evidence for adaptive multigenerational plasticity is, and we use these criteria to critically examine putative cases of it in C. elegans. We conclude by suggesting potentially fruitful avenues for future research.
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页数:13
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共 68 条
[1]   Transgenerational induction of defences in animals and plants [J].
Agrawal, AA ;
Laforsch, C ;
Tollrian, R .
NATURE, 1999, 401 (6748) :60-63
[2]   Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans [J].
Alcazar, Rosa M. ;
Lin, Rueyling ;
Fire, Andrew Z. .
GENETICS, 2008, 180 (03) :1275-1288
[3]  
[Anonymous], 1998, MATERNAL EFFECTS ADA
[4]  
Beltran T, 2020, BIORXIV, DOI [10.1101/2019.12.29.890194, DOI 10.1101/2019.12.29.890194]
[5]  
Bonduriansky R., 2018, EXTENDED HEREDITY NE
[6]   Transgenerational Epigenetic Inheritance [J].
Boskovic, Ana ;
Rando, Oliver J. .
ANNUAL REVIEW OF GENETICS, VOL 52, 2018, 52 :21-41
[7]   Evolutionary tipping points in the capacity to adapt to environmental change [J].
Botero, Carlos A. ;
Weissing, Franz J. ;
Wright, Jonathan ;
Rubenstein, Dustin R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (01) :184-189
[8]   A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality [J].
Buckley, Bethany A. ;
Burkhart, Kirk B. ;
Gu, Sam Guoping ;
Spracklin, George ;
Kershner, Aaron ;
Fritz, Heidi ;
Kimble, Judith ;
Fire, Andrew ;
Kennedy, Scott .
NATURE, 2012, 489 (7416) :447-451
[9]   Predicting mutation outcome from early stochastic variation in genetic interaction partners [J].
Burga, Alejandro ;
Olivia Casanueva, M. ;
Lehner, Ben .
NATURE, 2011, 480 (7376) :250-U133
[10]   Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection [J].
Burton, Nicholas O. ;
Riccio, Cristian ;
Dallaire, Alexandra ;
Price, Jonathan ;
Jenkins, Benjamin ;
Koulman, Albert ;
Miska, Eric A. .
NATURE COMMUNICATIONS, 2020, 11 (01)