Super-efficient in Vivo Two-Photon Photodynamic Therapy with a Gold Nanocluster as a Type I Photosensitizer

被引：131

作者：

Han, Rongcheng ^{[1
,3
]}

Zhao, Miao ^{[2
]}

Wang, Zhiwei ^{[1
,3
]}

Liu, Helin ^{[2
]}

Zhu, Shengcang ^{[1
,3
]}

Huang, Lu ^{[1
,3
]}

Wang, Yu ^{[1
,3
]}

Wang, Lijun ^{[2
]}

Hong, Yuankai ^{[2
]}

Sha, Yinlin ^{[2
]}

Jiang, Yuqiang ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China

[2] Peking Univ, Sch Basic Med Sci, Dept Biochem & Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ACS NANO | 2020年 / 14卷 / 08期

基金：

中国国家自然科学基金;

关键词：

photodynamic therapy; gold nanocluster; type I photochemical mechanism; two photon; in vivo; LYSOSOMAL MEMBRANE PERMEABILIZATION; CYTOCHROME-C RELEASE; SINGLET-OXYGEN; SILICA NANOPARTICLES; CANCER; GENERATION; MECHANISMS; EXCITATION; APOPTOSIS; CELLS;

D O I：

10.1021/acsnano.9b05169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic technique that can induce the regression of targeted lesions via generating excess cytotoxic reactive oxygen species. However, due to the limited penetration depth of visible excitation light and the intrinsic hypoxia microenvironment of solid tumors, the efficacy of PDT in the treatment of cancer, especially deep-seated or large tumors, is unsatisfactory. Herein, we developed an efficient in vivo PDT system based on a nanomaterial, dihydrolipoic acid coated gold nanocluster (AuNC@DHLA), that combined the advantages of large penetration depth in tissue, extremely high two-photon (TP) absorption cross section (sigma(2) similar to 10(6) GM), efficient ROS generation, a type I photochemical mechanism, and negligible in vivo toxicity. With AuNC@DHLA as the photosensitizer, highly efficient in vivo TP-PDT has been achieved.

引用

页码：9532 / 9544

页数：13

共 60 条

[1]

[Anonymous], 2013, OPTICAL PROPERTIES M

[2]

Bhawalkar J D, 1997, J Clin Laser Med Surg, V15, P201

[3] PHOTOSENSITIZERS OF THE PORPHYRIN AND PHTHALOCYANINE SERIES FOR PHOTODYNAMIC THERAPY [J].