Tandem amine propargylation-Sonogashira reactions: new three-component coupling leading to functionalized substituted propargylic amines

被引：32

作者：

Olivi, NL ^{[1
]}

Spruyt, P ^{[1
]}

Peyrat, JF ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Univ Paris Sud, CNRS UMR 8076, BioCIS,Fac Pharm, Chim Therapeut Lab, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 12期

关键词：

Sonogashira; propargyl halides; propargylic amines; palladium; 2-(dialkylaminomethyi)indoles; 2-(dialkylaminomethyl)benzofuranes;

D O I：

10.1016/j.tetlet.2004.01.141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium-copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to the synthesis of 2-(dialkylaminomethyl)benzo[b]furan or indole derivatives is described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2607 / 2610

页数：4

共 37 条

[1]

Alami M, 2002, ANGEW CHEM INT EDIT, V41, P1578, DOI 10.1002/1521-3773(20020503)41:9<1578::AID-ANIE1578>3.0.CO

[2]

2-C

[3] Stereoselective synthesis of (E)-chloroenynes or (E,E)-chlorodienes starting from a stereoisomeric mixture of 1,2-dichloroethylenes [J].