Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release

被引：77

作者：

Kong, Seong Deok ^{[1
]}

Sartor, Marta ^{[1
]}

Hu, Che-Ming Jack ^{[2
]}

Zhang, Weizhou ^{[3
]}

Zhang, Liangfang ^{[2
]}

Jin, Sungho ^{[1
,4
]}

机构：

[1] Univ Calif San Diego, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA

来源：

ACTA BIOMATERIALIA | 2013年 / 9卷 / 03期

基金：

美国国家科学基金会;

关键词：

Lipid-polymer hybrid nanoparticles; Magnetic beads; Drug delivery; Controlled drug release; THERAPEUTIC APPLICATIONS; DELIVERY PLATFORM; NANOTECHNOLOGY; CANCER; NANOMEDICINE; DIAGNOSIS; SYSTEMS;

D O I：

10.1016/j.actbio.2012.11.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Stimuli-responsive nanoparticles (SRNPs) offer the potential of enhancing the therapeutic efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the encapsulated drug at the target site. Currently controlled drug release through external activation remains a major challenge during the delivery of therapeutic agents. Here we report a lipid-polymer hybrid nanoparticle system containing magnetic beads for stimuli-responsive drug release using a remote radio frequency (RF) magnetic field. These hybrid nanoparticles show long-term stability in terms of particle size and polydispersity index in phosphate-buffered saline (PBS). Controllable loading of camptothecin (CPT) and Fe3O4 in the hybrid nanoparticles was demonstrated. RF-controlled drug release from these nanoparticles was observed. In addition, cellular uptake of the SRNPs into MT2 mouse breast cancer cells was examined. Using CPT as a model anticancer drug the nanoparticles showed a significant reduction in MT2 mouse breast cancer cell growth in vitro in the presence of a remote RF field. The ease of preparation, stability, and controllable drug release are the strengths of the platform and provide the opportunity to improve cancer chemotherapy. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：5447 / 5452

页数：6