Nuclear localization of folate receptor alpha: a new role as a transcription factor

被引：78

作者：

Boshnjaku, Vanda ^{[1
,2
]}

Shim, Kyu-Won ^{[1
,2
,3
]}

Tsurubuchi, Takao ^{[1
,2
,4
]}

Ichi, Shunsuke ^{[1
,2
]}

Szany, Elise V. ^{[1
,2
]}

Xi, Guifa ^{[1
,2
]}

Mania-Farnell, Barbara ^{[5
]}

McLone, David G. ^{[1
,2
]}

Tomita, Tadanori ^{[1
,2
]}

Mayanil, C. Shekhar ^{[1
,2
]}

机构：

[1] Ann & Robert H Lurie Childrens Hosp, Dept Pediat Neurosurg, Chicago Res Ctr, Chicago, IL 60614 USA

[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60614 USA

[3] Yonsei Univ, Coll Med, Severance Childrens Hosp, Dept Pediat Neurosurg, Seoul, South Korea

[4] Univ Tsukuba, Dept Neurosurg, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki, Japan

[5] Purdue Univ Calumet, Dept Biol, Hammond, IN 46323 USA

来源：

SCIENTIFIC REPORTS | 2012年 / 2卷

关键词：

FOLIC-ACID; MICE LACKING; PAX3; BINDING; ENDOCYTOSIS; CAVEOLIN-1; TRANSPORT; MEMBRANE; CANCER; GENES;

D O I：

10.1038/srep00980

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA in human health and disease expands, it also becomes more critical to understand the mechanisms behind FA action. In this work we examined the hypothesis that folate receptor alpha (FR alpha) acts as a transcription factor. FR alpha is a GPI-anchored protein and a component of the caveolae fraction. The work described here shows that FR alpha translocates to the nucleus, where it binds to cis-regulatory elements at promoter regions of Fgfr4 and Hes1, and regulates their expression. The FR alpha recognition domain mapped to AT rich regions on the promoters. Until this time FR alpha has only been considered as a folate transporter, these studies describe a novel role for FRa as a transcription factor.

引用

页数：7

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