Systematic profiling of immune signatures identifies prognostic predictors in lung adenocarcinoma

被引：10

作者：

Mao, Shuangshuang ^{[1
]}

Li, Yuan ^{[1
]}

Lu, Zhiliang ^{[1
]}

Che, Yun ^{[1
]}

Huang, Jianbing ^{[1
]}

Lei, Yuanyuan ^{[1
]}

Wang, Yalong ^{[1
]}

Wang, Xinfeng ^{[1
]}

Liu, Chengming ^{[1
]}

Zheng, Sufei ^{[1
]}

Li, Ning ^{[1
]}

Li, Jiagen ^{[1
]}

Sun, Nan ^{[1
]}

He, Jie ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Thorac Surg,Canc Hosp, Beijing 100021, Peoples R China

来源：

CELLULAR ONCOLOGY | 2020年 / 43卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Lung adenocarcinoma; Overall survival; Immune signatures; Prognostic model; NF-KAPPA-B; CANCER STATISTICS; GENE-EXPRESSION; PD-1; BLOCKADE; TUMORS IMPACT; DOCETAXEL; CELLS; CD36; INFILTRATION; INFLAMMATION;

D O I：

10.1007/s13402-020-00515-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Lung adenocarcinoma (LUAD) is the predominant subtype of lung cancer, with increasing evidence showing clinical benefits of immunotherapy. However, a lack of integrated profiles of complex LUAD immune microenvironments hampers the application of immunotherapy, resulting in limited eligible patient populations as well as drug resistance problems. Here, we aimed to systematically profile the immune signatures of LUADs and to assess the role of the immune microenvironment in patient outcome. Methods We systematically profiled the immune signatures of LUADs deposited in the TCGA and GEO databases using a total of 730 immune-related genes. Differential expression analysis was used to identify dysregulated genes. Univariate Cox analysis followed by robust likelihood-based survival analysis and multivariate Cox analysis were applied to construct an immune-related prognostic model. Results We found that differentially expressed immune genes were mainly enriched in immune cell proliferation, migration, activation and the NF-kappa B and TNF signaling pathways. The 10-immune gene predictive model that we constructed could differentiate LUAD patients with different overall survival times in several datasets, with areas under the curve (AUCs) of 0.67, 0.69, 0.72 and 0.74. LUAD patients with high- or low-risk scores exhibited distinct immune cell compositions, which may explain the prognostic significance of our model. Conclusions Our results add to the current knowledge of immune processes in LUADs and underscore the critical role of the immune microenvironment in LUAD patient outcome.

引用

页码：681 / 694

页数：14

共 62 条

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