Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus

被引：6
作者：
Tan, Ming [1 ]
Jiang, Xi [1 ]
机构：
[1] Univ Cincinnati Coll Med, Div Infect Dis, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
来源：
NANOMEDICINE | 2012年 / 7卷 / 06期
关键词：
antigen presentation; bivalent vaccine; calicivirus; influenza virus; M2e epitope; norovirus; P domain; P particle; rotavirus VP8; vaccine platform; BLOOD GROUP ANTIGENS; INTEGRAL MEMBRANE-PROTEIN; INFECTED-CELL SURFACE; COWPEA MOSAIC-VIRUS; NORWALK VIRUS; CAPSID PROTEIN; RECEPTOR-BINDING; HOST INTERACTION; STRUCTURAL BASIS; GII-4; NOROVIRUS;
D O I：
10.2217/NNM.12.62
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Noroviruses (NoVs) are important pathogens causing epidemic acute gastroenteritis that affects millions of people worldwide. The protruding (P) domain of the NoV capsid protein, the surface antigen of NoV, forms a 24-mer subviral particle called the P particle that is an excellent candidate vaccine against NoVs. The P particles are easily produced in Escherichia coli, highly stable and highly immunogenic. Each P domain has three surface loops that can be used for foreign antigen presentation, making the P particles a useful platform for vaccine development against other infectious diseases. This article summarizes the discovery, structure, development and applications of the P particles as a vaccine against NoVs, as well as a vaccine platform against rotavirus, influenza virus and possibly other pathogens in the future.
引用
收藏
页码：889 / 897
页数：9
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