Catalytic Asymmetric Addition of Alkyllithium Reagents to Aromatic Aldehydes

被引：27

作者：

Fernandez-Mateos, Emilio ^{[1
,2
]}

Macia, Beatriz ^{[1
,2
]}

Yus, Miguel ^{[1
,2
]}

机构：

[1] Univ Alicante, Dept Organ Chem, E-03080 Alicante, Spain

[2] Univ Alicante, Inst Organ Synth, E-03080 Alicante, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 20期

关键词：

Asymmetric catalysis; Lithium; Aldehydes; Chirality; Titanium; GRIGNARD-REAGENTS; ENANTIOSELECTIVE ADDITION; ORGANOMETALLIC REAGENTS; ORGANOLITHIUM REAGENTS; DIORGANOZINC REAGENTS; STEREOGENIC CENTERS; ARYL; ALKYLATION; 1,2-ADDITION; ARYLATION;

D O I：

10.1002/ejoc.201200464

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the first efficient catalytic system for the asymmetric alkylation of aldehydes with organolithium reagents in the presence of titanium(IV) isopropoxide. A variety of alkyllithium reagents can be added to aromatic aldehydes in good yields with high enantioselectivities in a simple one-pot procedure under mild conditions.

引用

页码：3732 / 3736

页数：5

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