Eosinophil granule cationic proteins: eosinophil activation markers

被引：10
|
作者：
Guilpain, P.
Guillevin, L.
Mouthon, L.
机构：
[1] Univ Paris Descartes, Assistance Publ Hop Paris, Fac Med,Serv Med Interne, Hop Cochin,Ctr Reference Vasc Necrosantes & Scler, F-75679 Paris 14, France
[2] Univ Paris Descartes, Fac Med, UPRES EA 1833, Paris, France
来源：
REVUE DE MEDECINE INTERNE | 2006年 / 27卷 / 05期
关键词：
eosinophil; eosmophil cationic protein; eosinophil derived neurotoxin; allergy; Churg-Strauss syndrome;
D O I：
10.1016/j.revmed.2006.01.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction. - Eosinophils play a central role in the pathogenesis of allergic diseases and host protection against parasites, especially against helminths. Exegesis. - Eosinophil granules contain cytotoxic proteins, including cationic proteins: major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil derived neurotoxin (EDN). Conclusion. - Eosinophil granule proteins are implicated in the occurrence of allergic diseases and Churg-Strauss syndrome. These proteins are activation markers of eosinophils and may be useful in clinical practice. (C) 2006 Elsevier SAS. Tons droits reserves.
引用
收藏
页码：406 / 408
页数：3
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