Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I

被引：28
作者：
Fillet, AM
Auray, L
Alain, S
Gourlain, K
Imbert, BM
Najioullah, F
Champier, G
Gouarin, S
Carquin, J
Houhou, N
Garrigue, I
Ducancelle, A
Thouvenot, D
Mazeron, MC
机构：
[1] Hosp APHP Pitie Salpetriere, Virol Labs, Paris, France
[2] Univ Paris 06, Paris, France
[3] Hosp APHP Bichat Claude Bernard, Paris, France
[4] Hosp APHP Lariboisiere, Paris, France
[5] Teaching Hosp, Limoges, France
[6] Teaching Hosp, Nantes, France
[7] Hosp Clemenceau, Caen, France
[8] Hosp Robert Debre, Reims, France
[9] Hosp Pellegrin, Bordeaux, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 05期
关键词：
D O I：
10.1128/AAC.48.5.1865-1868.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
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页码：1865 / 1868
页数：4
相关论文
共 35 条
[1]   Failure of ganciclovir treatment associated with selection of a ganciclovir-resistant cytomegalovirus strain in a lung transplant recipient [J].
Alain, S ;
Honderlick, P ;
Grenet, D ;
Stern, M ;
Vadam, C ;
SansonLePors, MJ ;
Mazeron, MC .
TRANSPLANTATION, 1997, 63 (10) :1533-1536
[2]   Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS [J].
Baldanti, F ;
Underwood, MR ;
Stanat, SC ;
Biron, KK ;
Chou, SW ;
Sarasini, A ;
Silini, E ;
Gerna, G .
JOURNAL OF VIROLOGY, 1996, 70 (03) :1390-1395
[3]   Human cytomegalovirus resistance to antiviral drugs: diagnosis, monitoring and clinical impact [J].
Baldanti, F ;
Gerna, G .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (03) :324-330
[4]   Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis [J].
Boivin, G ;
Gilbert, C ;
Gaudreau, A ;
Greenfield, I ;
Sudlow, R ;
Roberts, NA .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (12) :1598-1602
[5]   Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis [J].
Bowen, EF ;
Emery, VC ;
Wilson, P ;
Johnson, MA ;
Davey, CC ;
Sabin, CA ;
Farmer, D ;
Griffiths, PD .
AIDS, 1998, 12 (06) :605-611
[6]   COMPILATION, ALIGNMENT, AND PHYLOGENETIC-RELATIONSHIPS OF DNA-POLYMERASES [J].
BRAITHWAITE, DK ;
ITO, J .
NUCLEIC ACIDS RESEARCH, 1993, 21 (04) :787-802
[7]   Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir [J].
Chou, S ;
Waldemer, RH ;
Senters, AE ;
Michels, KS ;
Kemble, GW ;
Miner, RC ;
Drew, WL .
JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (02) :162-169
[8]   Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy [J].
Chou, SW ;
Marousek, G ;
Parenti, DM ;
Gordon, SM ;
La Voy, AG ;
Ross, JG ;
Miner, RC ;
Drew, WL .
JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (02) :526-530
[9]   Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus [J].
Chou, SW ;
Lurain, NS ;
Thompson, KD ;
Miner, RC ;
Drew, WL .
JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (01) :32-39
[10]   Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance [J].
Chou, SW ;
Lurain, NS ;
Weinberg, A ;
Cai, GY ;
Sharma, PL ;
Crumpacker, CS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1500-1502
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