A genetic dissection of the retinoid signalling pathway in the mouse

被引:89
作者
Mark, M [1 ]
Ghyselinck, NB [1 ]
Wendling, O [1 ]
Dupé, V [1 ]
Mascrez, B [1 ]
Kastner, P [1 ]
Chambon, P [1 ]
机构
[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France
关键词
retinoic acid receptors; retinoic acid-binding protein; retinoic acid signalling pathway;
D O I
10.1017/S0029665199000798
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.
引用
收藏
页码:609 / 613
页数:5
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