Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis

被引：24

作者：

Castelli, Anthony A. ^{[1
]}

Rosenthal, David G. ^{[2
]}

Ignacio, Rachel Bender ^{[3
,4
]}

Chu, Helen Y. ^{[3
]}

机构：

[1] Univ Washington, Sch Med, Seattle, WA USA

[2] Univ Washington, Dept Med, Seattle, WA USA

[3] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[4] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Global Oncol, Seattle, WA 98104 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2015年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

histoplasmosis; HIV; HLH; CHRONIC LYMPHOCYTIC-LEUKEMIA; REACTIVE HEMOPHAGOCYTOSIS; INFLAMMATORY SYNDROME; PATIENT; INFECTION; AIDS;

D O I：

10.1093/ofid/ofv140

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.

引用

页数：4

共 21 条

[1] Hemophagocytic syndrome after highly active antiretroviral therapy initiation: a life-threatening event related to immune restoration inflammatory syndrome? [J].