The role of long non-coding RNA MIAT in cancers

被引：44
作者：
Da, Chao-ming [1 ,2 ]
Gong, Chao-Yang [1 ,2 ]
Nan, Wei [1 ]
Zhou, Kai-Sheng [1 ]
Wu, Zuo-Long [1 ,2 ]
Zhang, Hai-Hong [1 ,2 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 2, 82 Cuiying Men, Lanzhou 730030, Peoples R China
[2] Orthopaed Key Lab Gansu Prov, Lanzhou 730000, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 129卷
基金：
中国国家自然科学基金;
关键词：
MIAT; LncRNA; Cancer; Biomarker; CELL LUNG-CANCER; MEDIATED REGULATION; LNCRNA; METASTASIS; PROMOTES; CERNA; CLASSIFICATION; PROLIFERATION; EXPRESSION; GROWTH;
D O I：
10.1016/j.biopha.2020.110359
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Long non-coding RNAs (lncRNAs), a kind of non-coding single-strand RNAs, play an important role as carcinogenic genes or tumor suppressors in the development of human cancer. Myocardial infarction-associated transcript (MIAT) was first identified as a lncRNA in 2006 and originally isolated as a candidate gene for myocardial infarction. Later, it was reported that MIAT exhibits regulatory effects on the human cell cycle. Since its discovery, MIAT has also been identified as a carcinogenic regulator in many malignant tumors. High expression of MIAT is related to the clinicopathological characteristics of cancer patients. It can also regulate cell proliferation, invasion, metastasis, and anti-apoptosis through a variety of mechanisms. Therefore, MIAT is considered a potential biomarker and therapeutic target in cancer. In this review, we summarize the biological function, mechanism, and potential clinical significance of MIAT during tumorigenesis.
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页数：10
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