The role of long non-coding RNA MIAT in cancers

被引：44

作者：

Da, Chao-ming ^{[1
,2
]}

Gong, Chao-Yang ^{[1
,2
]}

Nan, Wei ^{[1
]}

Zhou, Kai-Sheng ^{[1
]}

Wu, Zuo-Long ^{[1
,2
]}

Zhang, Hai-Hong ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Clin Med Coll 2, 82 Cuiying Men, Lanzhou 730030, Peoples R China

[2] Orthopaed Key Lab Gansu Prov, Lanzhou 730000, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 129卷

基金：

中国国家自然科学基金;

关键词：

MIAT; LncRNA; Cancer; Biomarker; CELL LUNG-CANCER; MEDIATED REGULATION; LNCRNA; METASTASIS; PROMOTES; CERNA; CLASSIFICATION; PROLIFERATION; EXPRESSION; GROWTH;

D O I：

10.1016/j.biopha.2020.110359

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Long non-coding RNAs (lncRNAs), a kind of non-coding single-strand RNAs, play an important role as carcinogenic genes or tumor suppressors in the development of human cancer. Myocardial infarction-associated transcript (MIAT) was first identified as a lncRNA in 2006 and originally isolated as a candidate gene for myocardial infarction. Later, it was reported that MIAT exhibits regulatory effects on the human cell cycle. Since its discovery, MIAT has also been identified as a carcinogenic regulator in many malignant tumors. High expression of MIAT is related to the clinicopathological characteristics of cancer patients. It can also regulate cell proliferation, invasion, metastasis, and anti-apoptosis through a variety of mechanisms. Therefore, MIAT is considered a potential biomarker and therapeutic target in cancer. In this review, we summarize the biological function, mechanism, and potential clinical significance of MIAT during tumorigenesis.

引用

页数：10

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