Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

被引：97

作者：

Chiu, Bo-Chin ^{[1
]}

Martin, Brian E. ^{[1
]}

Stolberg, Valerie R. ^{[2
]}

Chensue, Stephen W. ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Vet Adm Ann Arbor Healthcare Syst, Dept Pathol & Lab Med, Ann Arbor, MI 48105 USA

来源：

JOURNAL OF IMMUNOLOGY | 2013年 / 191卷 / 12期

基金：

美国国家卫生研究院;

关键词：

DIFFERENTIATION; PHENOTYPE; PROLIFERATION; MAINTENANCE; RESPONSES; EFFECTOR;

D O I：

10.4049/jimmunol.1302509

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The number of memory phenotype CD8 T cells increases dramatically with aging in both humans and mice. However, the mechanism for this is unknown. The prevailing hypothesis is that memory T cells accumulate with aging as a result of lifelong antigenic stimulation. However, data supporting this supposition are lacking. In this study, we demonstrate that central memory CD8 T cells, which represent a large majority of memory CD8 T cells in aged mice, are not memory cells that develop in response to antigenic stimulation but are virtual memory cells that develop without antigenic stimulation. In addition to phenotypic evidence, we show that accumulation of central memory CD8 T cells is independent of CD4 T cells, CCR5, and CXCR3, all of which are known to be essential for Ag-driven development of central memory CD8 T cells. Thus, this study reveals a novel mechanism for aging-related changes in CD8 T cells.

引用

页码：5793 / 5796

页数：4

共 17 条

[1] Derivation and Maintenance of Virtual Memory CD8 T Cells [J].

Akue, Adovi D. ;

Lee, June-Yong ;

Jameson, Stephen C. .

JOURNAL OF IMMUNOLOGY, 2012, 188 (06) :2516-2523

[2]

Chao CC, 1997, J IMMUNOL, V159, P1686

[3]

Chiu BC, 2002, J LEUKOCYTE BIOL, V72, P363

[4] Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation [J].

Goldrath, AW ;

Bogatzki, LY ;

Bevan, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :557-564

[5] The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion [J].

Haluszczak, Catherine ;

Akue, Adovi D. ;

Hamilton, Sara E. ;

Johnson, Lisa D. S. ;

Pujanauski, Lindsey ;

Teodorovic, Lenka ;

Jameson, Stephen C. ;

Kedl, Ross M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (02) :435-448

[6] The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells [J].

Hamilton, SE ;

Wolkers, MC ;

Schoenberger, SP ;

Jameson, SC .

NATURE IMMUNOLOGY, 2006, 7 (05) :475-481

[7] Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses [J].

Hugues, Stephanie ;

Scholer, Alix ;

Boissonnas, Alexandre ;

Nussbaum, Alexander ;

Combadiere, Christophe ;

Amigorena, Sebastian ;

Fetler, Luc .

NATURE IMMUNOLOGY, 2007, 8 (09) :921-930

[8] Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells [J].

Intlekofer, Andrew M. ;

Takemoto, Naofumi ;

Kao, Charlly ;

Banerjee, Arnob ;

Schambach, Felix ;

Northrop, John K. ;

Shen, Hao ;

Wherry, E. John ;

Reiner, Steven L. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (09) :2015-2021

[9] Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration [J].

Kurachi, Makoto ;

Kurachi, Junko ;

Suenaga, Fumiko ;

Tsukui, Tatsuya ;

Abe, Jun ;

Ueha, Satoshi ;

Tomura, Michio ;

Sugihara, Kei ;

Takamura, Shiki ;

Kakimi, Kazuhiro ;

Matsushima, Kouji .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (08) :1605-1620

[10] Virtual memory CD8 T cells display unique functional properties [J].

Lee, June-Yong ;

Hamilton, Sara E. ;

Akue, Adovi D. ;

Hogquist, Kristin A. ;

Jameson, Stephen C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (33) :13498-13503

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