Desmoplastic melanoma: a challenge for the oncologist

被引：7

作者：

Manfredini, Marco ^{[1
]}

Pellacani, Giovanni ^{[1
]}

Losi, Lorena ^{[2
]}

Maccaferri, Monia ^{[3
]}

Tomasi, Aldo ^{[3
]}

Ponti, Giovanni ^{[3
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Surg Med Dent & Morphol Sci Interest Transpl, Dermatol Unit, Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Pathol, Modena, Italy

[3] Univ Modena & Reggio Emilia, Dept Diagnost & Clin Med & Publ Hlth, Clin Pathol Unit, Modena, Italy

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 04期

关键词：

desmoplastic melanoma; lentigo maligna melanoma; mixed desmoplastic melanoma; NF1; pure desmoplastic melanoma; spindle cell melanoma; stromal collagenization; PRIMARY ACQUIRED MELANOSIS; MALIGNANT-MELANOMA; MELANOCYTIC NEVI; CONJUNCTIVAL MELANOMA; NEUROTROPIC MELANOMA; MUTATIONS; NEUROFIBROMATOSIS; CANCER; SKIN; EXPRESSION;

D O I：

10.2217/fon-2016-0334

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM). Materials & methods: Analysis of all DM records from 1991 to 2015. Results: The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4.5 mm) was observed in 'pure' DM. Conclusion: DM could progress from an early phase, characterized by an intraepidermal component, to late phase, characterized by a dermal nodule. This hypothesis correlates with melanoma genetic and NF1 mutation, which could be an early event in the progression of DM.

引用

页码：337 / 345

页数：9

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