Self-Adjuvanting Polymer-Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

被引：86
作者：
Liu, Tzu-Yu [1 ]
Hussein, Waleed M. [1 ]
Jia, Zhongfan [2 ]
Ziora, Zyta M. [1 ]
McMillan, Nigel A. J. [3 ,4 ]
Monteiro, Michael J. [2 ]
Toth, Istvan [1 ,5 ]
Skwarczynski, Mariusz [1 ]
机构：
[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia
[3] Griffith Univ, Canc Res Ctr, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia
[4] Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia
[5] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
来源：
BIOMACROMOLECULES | 2013年 / 14卷 / 08期
基金：
英国医学研究理事会;
关键词：
ACYL ISOPEPTIDE METHOD; SEQUENCE-CONTAINING PEPTIDES; AMYLOID-BETA PEPTIDE; HUMAN-PAPILLOMAVIRUS; MIGRATION REACTION; CLICK CHEMISTRY; DELIVERY; IMMUNOTHERAPY; NANOPARTICLES; DENDRIMERS;
D O I：
10.1021/bm400626w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.
引用
收藏
页码：2798 / 2806
页数：9
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