Treatment of implant-associated infections with moxifloxacin:: An animal study

The efficacy of moxifloxacin in the treatment of an implant-associated infection by Staphylococcus aureus was compared with vancomycin in an animal study. The femoral medullary cavity of 36 Wistar rats was contaminated with S. aureus (ATCC 29213) and a metal device was implanted. After treatment for 14 days with moxifloxacin (2 x 10 mg/kg/day) or vancomycin (2 x 15 mg/kg/day), the bacterial counts (colony-forming units) in the periprosthetic bone, the soft tissue and the implant-associated biofilm were measured. Compared with the control group, moxifloxacin achieved a highly significant decrease in the microbial counts in the bone and soft tissue and in the biofilm (P < 0.001). Moreover, the efficacy of moxifloxacin was significantly greater than that of vancomycin (P < 0.01). Vancomycin did not reduce the microbial count significantly compared with the control group (P > 0.05). The results justify further investigations of the treatment of implant-associated infections due to S. aureus with moxifloxacin. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.