Transition-Metal-Free Synthesis of Trifluoromethylated Furans via a Bu3P-Mediated Tandem Acylation-Wittig Reaction

被引:2
作者
Li, Maizhan [1 ]
Zhou, Wei [1 ]
机构
[1] Jinan Univ, Int Cooperat Lab Tradit Chinese Med Modernizat &, Chinese Minist Educ, Coll Pharm, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China
关键词
beta-trifluoromethyl; alpha; beta-enones; Wittig reaction; nucleophilic addition; furans; trifluoromethylated furans; TETRASUBSTITUTED FURANS; FUNCTIONAL BENZOFURANS; FLUORINE; ADDITIONS; INDOLES; AMIDE;
D O I
10.1055/s-0040-1707263
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly efficient nucleophilic addition-O-acylation-intramolecular Wittig reaction of beta-trifluoromethyl alpha,beta-enones is disclosed. This strategy features mild reaction conditions and provides a practical transition-metal-free method to a set of biologically significant trifluoromethylated furans in high yields with diverse functional groups.
引用
收藏
页码:2035 / 2038
页数:4
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