Iodine-Catalyzed Etherification of Morroniside

被引：14

作者：

Sunghwa, Fortunatus ^{[2
]}

Sakurai, Hiroaki ^{[3
]}

Saiki, Ikuo ^{[3
]}

Koketsu, Mamoru ^{[1
]}

机构：

[1] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan

[2] Univ Dar Es Salaam, Fac Sci, Dept Chem, Dar Es Salaam, Tanzania

[3] Toyama Univ, Inst Nat Med, Div Pathogen Biochem, Toyama 9300194, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 01期

关键词：

etherification; morroniside; cytotoxicity; CONVERSION; AUCUBIN; ASPERULOSIDE; SYNTHONS; ANALOG;

D O I：

10.1248/cpb.57.112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxie activity, having IC50 values equal to 20.9 mu M.

引用

页码：112 / 115

页数：4

共 26 条

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