Detection of volatile organic compounds as biomarkers in breath analysis by different analytical techniques

被引：78

作者：

Buszewski, Boguslaw ^{[1
]}

Grzywinski, Damian ^{[1
]}

Ligor, Tomasz ^{[1
]}

Stacewicz, Tadeusz ^{[2
]}

Bielecki, Zygmunt ^{[3
]}

Wojtas, Jacek ^{[3
]}

机构：

[1] Nicolaus Copernicus Univ, Fac Chem, Dept Environm Chem & Bioanalyt, PL-87100 Torun, Poland

[2] Univ Warsaw, Inst Expt Phys, PL-00068 Warsaw, Poland

[3] Mil Univ Technol, PL-00908 Warsaw, Poland

来源：

BIOANALYSIS | 2013年 / 5卷 / 18期

关键词：

TUBE MASS-SPECTROMETRY; RING-DOWN SPECTROSCOPY; ION MOBILITY SPECTROMETRY; LUNG-CANCER DETECTION; EXHALED NITRIC-OXIDE; ELECTRONIC NOSE; CAVITY RING; SENSOR ARRAY; GAS SENSORS; SIFT-MS;

D O I：

10.4155/bio.13.183

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Breath is a rich mixture containing numerous volatile organic compounds at trace amounts (ppbv-pptv level) such as: hydrocarbons, alcohols, ketones, aldehydes, esters or heterocycles. The presence of some of them depends on health status. Therefore, breath analysis might be useful for clinical diagnostics, therapy monitoring and control of metabolic or biochemical cell cycle products. This Review presents an update on the latest developments in breath analysis applied to diagnosing different diseases with the help of high-quality equipment. Efforts were made to fully and accurately describe traditional and modern techniques used to determine the components of breath. The techniques were compared in terms of design, function and also detection limit of different volatile organic compounds. GC with different detectors, MS, optical sensor and laser spectroscopic detection techniques are also discussed.

引用

页码：2287 / 2306

页数：20

共 137 条

[1] Gas sensing properties of defect-controlled ZnO-nanowire gas sensor [J].

Ahn, M. -W. ;

Park, K. -S. ;

Heo, J. -H. ;

Park, J. -G. ;

Kim, D. -W. ;

Choi, K. J. ;

Lee, J. -H. ;

Hong, S. -H. .

APPLIED PHYSICS LETTERS, 2008, 93 (26)

[2] High sensitive detection of volatile organic compounds using superhydrophobic quartz crystal microbalance [J].

Andreeva, Nina ;

Ishizaki, Takahiro ;

Baroch, Pavel ;

Saito, Nagahiro .

SENSORS AND ACTUATORS B-CHEMICAL, 2012, 164 (01) :15-21

[3] Photoacoustic spectroscopy of formaldehyde with tunable laser radiation at the parts per billion level [J].

Angelmahr, M. ;

Miklos, A. ;

Hess, P. .

APPLIED PHYSICS B-LASERS AND OPTICS, 2006, 85 (2-3) :285-288

[4]

[Anonymous], 2009, Cavity ring-down spectroscopy: Techniques and applications

[5] Alcohol vapours sensor based on thin polyaniline salt film and quartz crystal microbalance [J].

Ayad, Mohamad M. ;

Torad, Nagy L. .

TALANTA, 2009, 78 (4-5) :1280-1285

[6] Gas sensors based on conducting polymers [J].

Bai, Hua ;

Shi, Gaoquan .

SENSORS, 2007, 7 (03) :267-307

[7]

Bajtarevic A, 2009, BMC CANCER, V9, P1471

[8] Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection [J].

Bakhirkin, YA ;

Kosterev, AA ;

Roller, C ;

Curl, RF ;

Tittel, FK .

APPLIED OPTICS, 2004, 43 (11) :2257-2266

[9] Real-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules [J].

Beauchamp, J. ;

Kirsch, F. ;

Buettner, A. .

JOURNAL OF BREATH RESEARCH, 2010, 4 (02)

[10] Cavity ring-down spectroscopy: Experimental schemes and applications [J].

Berden, G ;

Peeters, R ;

Meijer, G .

INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY, 2000, 19 (04) :565-607

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