α-tricalcium phosphate cement:: "in vitro" cytotoxicity

被引：54
作者：
dos Santos, LA
Carrodéguas, RG
Rogero, SO
Higa, OZ
Boschi, AO
de Arruda, ACF
机构：
[1] Univ Estadual Campinas, UNICAMP, FEM, CEP, BR-13081970 Campinas, SP, Brazil
[2] Univ La Habana, Ctr Biomat, Havana 10600, Cuba
[3] CNEN, IPEN, BR-05422970 Sao Paulo, Brazil
[4] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP, Brazil
来源：
BIOMATERIALS | 2002年 / 23卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
citotoxicity; calcium phosphate cement; bioceramic; biomaterial;
D O I：
10.1016/S0142-9612(01)00333-7
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Calcium phosphate-based bioceramics have revolutionized orthopedic and dental repair of damaged parts of the bone system. Among these materials, calcium phosphate-based cements, with hydraulic setting, stand out due to their biocompatibility and in situ hardening, which allow easy manipulation and adaptation to the shape and dimensions of bone defects. An investigation was made of the in vitro cytotoxic effect of calcium phosphate cement based on a-tricalcium phosphate, immersed for different lengths of time in simulated body fluid (SBF), based on the ISO-10993 "Biological Evaluation of Medical Devices" standard. The culture medium was Chinese hamster ovary (CHO) cells in contact with diluted cement extracts. The results revealed that the calcium phosphate cement used was cytotoxic and that the material's cytotoxicity decreased the longer the cement was immersed in SBF. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2035 / 2042
页数：8
相关论文
共 29 条
  • [11] 2-Q
  • [12] Production and characterization of new calcium phosphate bone cements in the CaHPO4-α-Ca3(PO4)2 system:: pH, workability and setting times
    Fernández, E
    Gil, FJ
    Ginebra, MP
    Driessens, FCM
    Planell, JA
    Best, SM
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1999, 10 (04) : 223 - 230
  • [13] DIMENSIONAL AND THERMAL-BEHAVIOR OF CALCIUM-PHOSPHATE CEMENTS DURING SETTING COMPARED TO PMMA BONE CEMENTS
    FERNANDEZ, E
    GINEBRA, MP
    BERMUDEZ, O
    BOLTONG, MG
    DRIESSENS, FCM
    PLANELL, JA
    [J]. JOURNAL OF MATERIALS SCIENCE LETTERS, 1995, 14 (01) : 4 - 5
  • [14] APATITE FORMATION ON (2-X)CAO-CENTER-DOT-X/3 M(2)O(3)-CENTER-DOT-2SIO(2) GLASSES (M=LA,Y, 0-LESS-THAN-OR-EQUAL-TO-X LESS-THAN-OR-EQUAL-TO-0.6) IN A SIMULATED BODY-FLUID
    FRESA, R
    COSTANTINI, A
    BURI, A
    BRANDA, F
    [J]. BIOMATERIALS, 1995, 16 (16) : 1249 - 1253
  • [15] Setting reaction and hardening of an apatitic calcium phosphate cement
    Ginebra, MP
    Fernandez, E
    DeMaeyer, EAP
    Verbeeck, RMH
    Boltong, MG
    Ginebra, J
    Driessens, FCM
    Planell, JA
    [J]. JOURNAL OF DENTAL RESEARCH, 1997, 76 (04) : 905 - 912
  • [16] Ginebra MP, 1998, BIOCERAMICS, V11, P243
  • [17] GRUNINGER SE, 1984, J DENT RES, V63, P200
  • [18] International Organization for Standardization, 1992, 109935 ISO
  • [19] Ishikawa K, 1998, J DENT RES, V77, P812
  • [20] JENKINS R, 1971, INTRO XRAY POWDER DI
123