α-tricalcium phosphate cement:: "in vitro" cytotoxicity

被引：54
作者：
dos Santos, LA
Carrodéguas, RG
Rogero, SO
Higa, OZ
Boschi, AO
de Arruda, ACF
机构：
[1] Univ Estadual Campinas, UNICAMP, FEM, CEP, BR-13081970 Campinas, SP, Brazil
[2] Univ La Habana, Ctr Biomat, Havana 10600, Cuba
[3] CNEN, IPEN, BR-05422970 Sao Paulo, Brazil
[4] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP, Brazil
来源：
BIOMATERIALS | 2002年 / 23卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
citotoxicity; calcium phosphate cement; bioceramic; biomaterial;
D O I：
10.1016/S0142-9612(01)00333-7
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Calcium phosphate-based bioceramics have revolutionized orthopedic and dental repair of damaged parts of the bone system. Among these materials, calcium phosphate-based cements, with hydraulic setting, stand out due to their biocompatibility and in situ hardening, which allow easy manipulation and adaptation to the shape and dimensions of bone defects. An investigation was made of the in vitro cytotoxic effect of calcium phosphate cement based on a-tricalcium phosphate, immersed for different lengths of time in simulated body fluid (SBF), based on the ISO-10993 "Biological Evaluation of Medical Devices" standard. The culture medium was Chinese hamster ovary (CHO) cells in contact with diluted cement extracts. The results revealed that the calcium phosphate cement used was cytotoxic and that the material's cytotoxicity decreased the longer the cement was immersed in SBF. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2035 / 2042
页数：8
相关论文
共 29 条
  • [1] DEVELOPMENT OF AN OCTOCALCIUM PHOSPHATE CEMENT
    BERMUDEZ, O
    BOLTONG, MG
    DRIESSENS, FCM
    PLANELL, JA
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1994, 5 (03) : 144 - 146
  • [2] DEVELOPMENT OF SOME CALCIUM-PHOSPHATE CEMENTS FROM COMBINATIONS OF ALPHA-TCP, MCPM AND CAO
    BERMUDEZ, O
    BOLTONG, MG
    DRIESSENS, FCM
    PLANELL, JA
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1994, 5 (03) : 160 - 163
  • [3] CARRODEGUAS RG, UNPUB J MAT SCI MAT
  • [4] CARRODEGUAS RG, BIOMAT 97 C INT BIOM
  • [5] CHOW LC, 1991, NIPPON SERAM KYO GAK, V99, P954
  • [6] Fiber reinforced calcium phosphate cement
    dos Santos, LA
    de Oliveira, LC
    Rigo, ECD
    Carrodéguas, RG
    Boschi, AO
    de Arruda, ACF
    [J]. ARTIFICIAL ORGANS, 2000, 24 (03) : 212 - 216
  • [7] EFFECTIVE FORMULATIONS FOR THE PREPARATION OF CALCIUM-PHOSPHATE BONE CEMENTS
    DRIESSENS, FCM
    BOLTONG, MG
    BERMUDEZ, O
    PLANELL, JA
    GINEBRA, MP
    FERNANDEZ, E
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1994, 5 (03) : 164 - 170
  • [8] Driessens FCM, 1997, AN QUIM-INT, V93, pS38
  • [9] PREPARATION OF ALPHA-TRICALCIUM AND BETA-TRICALCIUM PHOSPHATE CERAMICS, WITH AND WITHOUT MAGNESIUM ADDITION
    FAMERY, R
    RICHARD, N
    BOCH, P
    [J]. CERAMICS INTERNATIONAL, 1994, 20 (05) : 327 - 336
  • [10] Fernandez E, 1996, J BIOMED MATER RES, V32, P367, DOI 10.1002/(SICI)1097-4636(199611)32:3<367::AID-JBM9>3.0.CO
123