Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

被引：11

作者：

Benoit, Matthieu P. M. H. ^{[1
,2
,3
]}

Plevin, Michael J. ^{[1
,2
,3
]}

机构：

[1] CEA, Inst Biol Struct Jean Pierre Ebel, F-38027 Grenoble, France

[2] CNRS, Inst Biol Struct Jean Pierre Ebel, F-38027 Grenoble, France

[3] Univ Grenoble 1, Inst Biol Struct Jean Pierre Ebel, F-38027 Grenoble, France

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2013年 / 7卷 / 02期

关键词：

TRBP; Triple resonance NMR experiments; Micro-RNA; Double-stranded RNA binding domain;

D O I：

10.1007/s12104-012-9416-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

引用

页码：229 / 233

页数：5

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