Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

被引：79

作者：

Kato, Takao ^{[1
]}

Yaku, Hidenori ^{[1
]}

Morimoto, Takeshi ^{[2
]}

Inuzuka, Yasutaka ^{[3
]}

Tamaki, Yodo ^{[4
]}

Yamamoto, Erika ^{[1
]}

Yoshikawa, Yusuke ^{[1
]}

Kitai, Takeshi ^{[5
]}

Taniguchi, Ryoji ^{[6
]}

Iguchi, Moritake ^{[7
]}

Kato, Masashi ^{[8
]}

Takahashi, Mamoru ^{[9
]}

Jinnai, Toshikazu ^{[10
]}

Ikeda, Tomoyuki ^{[11
]}

Nagao, Kazuya ^{[12
]}

Kawai, Takafumi ^{[13
]}

Komasa, Akihiro ^{[14
,15
]}

Nishikawa, Ryusuke ^{[16
]}

Kawase, Yuichi ^{[16
]}

Morinaga, Takashi ^{[17
]}

Su, Kanae ^{[18
]}

Kawato, Mitsunori ^{[19
]}

Seko, Yuta ^{[20
]}

Inoko, Moriaki ^{[20
]}

Toyofuku, Mamoru ^{[18
]}

Furukawa, Yutaka ^{[5
]}

Nakagawa, Yoshihisa ^{[4
]}

Ando, Kenji ^{[17
]}

Kadota, Kazushige ^{[16
]}

Shizuta, Satoshi ^{[1
]}

Ono, Koh ^{[1
]}

Sato, Yukihito ^{[6
]}

Kuwahara, Koichiro ^{[21
]}

Ozasa, Neiko ^{[1
]}

Kimura, Takeshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan

[2] Hyogo Coll Med, Dept Clin Epidemiol, Nishinomiya, Hyogo, Japan

[3] Shiga Med Ctr Adult, Dept Cardiovasc Med, Moriyama, Shiga, Japan

[4] Tenri Hosp, Div Cardiol, Nara, Japan

[5] Kobe City Med Ctr Gen Hosp, Dept Cardiovasc Med, Kobe, Hyogo, Japan

[6] Hyogo Prefectural Amagasaki Gen Med Ctr, Dept Cardiol, Amagasaki, Hyogo, Japan

[7] Natl Hosp Org Kyoto Med Ctr, Kyoto, Japan

[8] Mitsubishi Kyoto Hosp, Kyoto, Japan

[9] Shimabara Hosp, Kyoto, Japan

[10] Japanese Red Cross Otsu Hosp, Otsu, Shiga, Japan

[11] Hikone Municipal Hosp, Hikone, Shiga, Japan

[12] Osaka Red Cross Hosp, Osaka, Japan

[13] Kishiwada City Hosp, Osaka, Japan

[14] Kansai Elect Power Hosp, Osaka, Japan

[15] Shizuoka Prefectural Gen Hosp, Shizuoka, Japan

[16] Kurashiki Cent Hosp, Okayama, Japan

[17] Kokura Mem Hosp, Fukuoka, Japan

[18] Japanese Red Cross Wakayama Med Ctr, Wakayama, Japan

[19] Nishikobe Med Ctr, Kobe, Hyogo, Japan

[20] Kitano Hosp, Osaka, Japan

[21] Shinshu Univ, Grad Sch Med, Dept Cardiovasc Med, Matsumoto, Nagano, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

LYMPHOCYTE CONCENTRATION; PROGNOSTIC IMPORTANCE; IMPACT; RISK; MALNUTRITION; INFLAMMATION; CONGESTION; METABOLISM; CACHEXIA; POINT;

D O I：

10.1038/s41598-020-60404-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The high controlling nutritional status (CONUT) score that represents poor nutritional status has been acknowledged to have prognostic implications in chronic heart failure. We aimed to investigate its role in acute decompensated heart failure (ADHF). Using the data from an multicenter registry that enrolled 4056 consecutive patients hospitalized for ADHF in Japan between 2014 and 2016, we analyzed 2466 patients in whom data on the components of the CONUT score at hospital presentation were available. The decrease of lymphocyte count and total cholesterol was assigned with 0, 1, 2, and 3 points and the decrease of albumin was assigned with 0, 2, 4, and 6 points according to the severity. We defined low CONUT score as 0-4 (N = 1568) and high CONUT score as 5-9 (N = 898). The patients in the high CONUT score group were older and more likely to have a smaller body mass index than those in the low CONUT score group. The high CONUT score group was associated with higher rate of death and infection during the index hospitalization compared to the low CONUT score group (9.0% versus 4.4%, and 21.9% versus 12.7%, respectively). After adjusting for confounders, the excess risk of high relative to low CONUT score for mortality and infection was significant (OR: 1.61, 95%CI: 1.05-2.44, and OR: 1.66, 95%CI: 1.30-2.12, respectively). The effect was incremental according to the score. High CONUT score was associated with higher risk for in-hospital mortality and infection in an incremental manner in patients hospitalized for ADHF.

引用

页数：10

共 38 条

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