Copper-Catalyzed sp3 C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones

被引：64

作者：

Nozawa-Kumada, Kanako ^{[1
]}

Kadokawa, Jun ^{[1
]}

Kameyama, Takehiro ^{[1
]}

Kondo, Yoshinori ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 18期

基金：

日本学术振兴会;

关键词：

STACHYBOTRIN C; NEURITOGENIC COMPOUNDS; ALLYLIC OXIDATION; BONDS; AMIDATION; MECHANISM; DESIGN; STAUROSPORINE; ADJACENT; CARBONYLATION;

D O I：

10.1021/acs.orglett.5b02235

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of isoindolinones via copper-catalyzed sp(3) C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.

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收藏

页码：4479 / 4481

页数：3

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