Role of M402, a novel heparan sulfate mimetic, in pancreatic cancer cell invasion and metastasis: Inhibition of the Sonic Hedgehog pathway and heparanase activity

被引：3

作者：

Galcheva-Gargova, Zoya ^{[1
]}

Chu, Chia Lin ^{[1
]}

Long, Alison ^{[1
]}

Duffner, Jay ^{[1
]}

Holte, Kimberly ^{[1
]}

Schultes, Birgit Corinna ^{[1
]}

机构：

[1] Momenta Pharmaceut, Cambridge, MA USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 30卷 / 30期

关键词：

D O I：

10.1200/jco.2012.30.30_suppl.25

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：1

共 6 条

[1] M402, a heparan sulfate mimetic and novel candidate for the treatment of pancreatic cancer [J].

Schultes, Birgit Corinna ;

Lolkema, Martijn P. J. K. ;

Chu, Chia Lin ;

Zhou, He ;

Long, Alison ;

Lockley, Michelle ;

Avery, William ;

Kurtagic, Elma ;

Galcheva-Gargova, Zoya ;

Miller, Paul ;

Duffner, Jay ;

Maschek, Birgit J. ;

Jarlenski, Donna ;

Tuveson, David A. ;

Roach, Jim ;

Venkataraman, Ganesh ;

Kishimoto, Takashi K. ;

Flaherty, Keith T. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)

[2] M402, a novel heparan sulfate mimetic, inhibits pancreatic tumor growth and desmoplasia potentially via sonic hedgehog signaling in an orthotopic mouse model [J].

Chu, Chia Lin ;

Long, Alison ;

Honan, Christopher M. ;

Duffner, Jay ;

Avery, William ;

D'Alessandro, Josephine ;

Kishimoto, Takashi K. ;

Schultes, Birgit C. .

CANCER RESEARCH, 2012, 72

[3] M402, a novel heparan sulfate mimetic, modulates the desmoplastic response in an orthotopic pancreatic cancer model in mice [J].

Chu, Chia Lin ;

Long, Alison ;

Honan, Christopher M. ;

Duffner, Jay ;

Ayery, William ;

D'Alessandro, Josephine ;

Kishimoto, Takashi K. ;

Schultes, Birgit C. .

CANCER RESEARCH, 2011, 71

[4] M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis [J].

Zhou, He ;

Roy, Sucharita ;

Cochran, Edward ;

Zouaoui, Radouane ;

Chu, Chia Lin ;

Duffner, Jay ;

Zhao, Ganlin ;

Smith, Sean ;

Galcheva-Gargova, Zoya ;

Karlgren, Juliane ;

Dussault, Nancy ;

Kwan, Rain Y. Q. ;

Moy, Erick ;

Barnes, Marishka ;

Long, Alison ;

Honan, Chris ;

Qi, Yi Wei ;

Shriver, Zachary ;

Ganguly, Tanmoy ;

Schultes, Birgit ;

Venkataraman, Ganesh ;

Kishimoto, Takashi Kei .

PLOS ONE, 2011, 6 (06)

[5] M402, a heparan sulfate mimetic, inhibits tumor revascularization and invasiveness after high-dose taxane treatment in a mouse breast cancer model [J].

Schultes, Birgit C. ;

Chu, Chia L. ;

Long, Alison ;

D'Alessandro, Josephine ;

Honan, Christopher M. ;

Kishimoto, Takashi K. ;

Venkataraman, Ganesh .

CANCER RESEARCH, 2012, 72

[6] Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics [J].

Tang, Su-Ni ;

Fu, Junsheng ;

Nall, Dara ;

Rodova, Mariana ;

Shankar, Sharmila ;

Srivastava, Rakesh K. .

INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (01) :30-40

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