Role of M402, a novel heparan sulfate mimetic, in pancreatic cancer cell invasion and metastasis: Inhibition of the Sonic Hedgehog pathway and heparanase activity

被引:3
作者
Galcheva-Gargova, Zoya [1 ]
Chu, Chia Lin [1 ]
Long, Alison [1 ]
Duffner, Jay [1 ]
Holte, Kimberly [1 ]
Schultes, Birgit Corinna [1 ]
机构
[1] Momenta Pharmaceut, Cambridge, MA USA
关键词
D O I
10.1200/jco.2012.30.30_suppl.25
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
25
引用
收藏
页数:1
相关论文
共 6 条
[1]   M402, a heparan sulfate mimetic and novel candidate for the treatment of pancreatic cancer [J].
Schultes, Birgit Corinna ;
Lolkema, Martijn P. J. K. ;
Chu, Chia Lin ;
Zhou, He ;
Long, Alison ;
Lockley, Michelle ;
Avery, William ;
Kurtagic, Elma ;
Galcheva-Gargova, Zoya ;
Miller, Paul ;
Duffner, Jay ;
Maschek, Birgit J. ;
Jarlenski, Donna ;
Tuveson, David A. ;
Roach, Jim ;
Venkataraman, Ganesh ;
Kishimoto, Takashi K. ;
Flaherty, Keith T. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
[2]   M402, a novel heparan sulfate mimetic, inhibits pancreatic tumor growth and desmoplasia potentially via sonic hedgehog signaling in an orthotopic mouse model [J].
Chu, Chia Lin ;
Long, Alison ;
Honan, Christopher M. ;
Duffner, Jay ;
Avery, William ;
D'Alessandro, Josephine ;
Kishimoto, Takashi K. ;
Schultes, Birgit C. .
CANCER RESEARCH, 2012, 72
[3]   M402, a novel heparan sulfate mimetic, modulates the desmoplastic response in an orthotopic pancreatic cancer model in mice [J].
Chu, Chia Lin ;
Long, Alison ;
Honan, Christopher M. ;
Duffner, Jay ;
Ayery, William ;
D'Alessandro, Josephine ;
Kishimoto, Takashi K. ;
Schultes, Birgit C. .
CANCER RESEARCH, 2011, 71
[4]   M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis [J].
Zhou, He ;
Roy, Sucharita ;
Cochran, Edward ;
Zouaoui, Radouane ;
Chu, Chia Lin ;
Duffner, Jay ;
Zhao, Ganlin ;
Smith, Sean ;
Galcheva-Gargova, Zoya ;
Karlgren, Juliane ;
Dussault, Nancy ;
Kwan, Rain Y. Q. ;
Moy, Erick ;
Barnes, Marishka ;
Long, Alison ;
Honan, Chris ;
Qi, Yi Wei ;
Shriver, Zachary ;
Ganguly, Tanmoy ;
Schultes, Birgit ;
Venkataraman, Ganesh ;
Kishimoto, Takashi Kei .
PLOS ONE, 2011, 6 (06)
[5]   M402, a heparan sulfate mimetic, inhibits tumor revascularization and invasiveness after high-dose taxane treatment in a mouse breast cancer model [J].
Schultes, Birgit C. ;
Chu, Chia L. ;
Long, Alison ;
D'Alessandro, Josephine ;
Honan, Christopher M. ;
Kishimoto, Takashi K. ;
Venkataraman, Ganesh .
CANCER RESEARCH, 2012, 72
[6]   Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics [J].
Tang, Su-Ni ;
Fu, Junsheng ;
Nall, Dara ;
Rodova, Mariana ;
Shankar, Sharmila ;
Srivastava, Rakesh K. .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (01) :30-40