Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives

被引：40

作者：

Budakoti, Asha ^{[1
]}

Bhat, Abdul R. ^{[1
]}

Athar, Fareeda ^{[1
]}

Azam, Amir ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 08期

关键词：

chalcone; pyrazolines; thiocarbamoyl; quinoxaline; antiamoebic activity;

D O I：

10.1016/j.ejmech.2007.10.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A variety of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline were obtained by the refluxing of 1-N-thiocarbamoyl 3,5-diphenyl-2-pyrazoline with 2,3-dichloroquinoxaline. The chemical structures of the compounds were elucidated by UV, IR, H-1 NMR, and C-13 NMR spectroscopy. The purity of the compounds was confirmed by their elemental analysis. The antiamoebic activity of these compounds was evaluated by microdilution method against HMI:IMSS strain of Entamoeba histolytica and the IC50 values were compared with the standard drug metronidazole. Some of the quinoxaline derivatives showed less IC50 values than metronidazole. To elucidate the toxic effect, MTT assay was performed using kidney epithelial cell line. The results showed that all the compounds are non-toxic. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1749 / 1757

页数：9

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