Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis

被引：87

作者：

Han, Quan-Bin ^{[2
]}

Yang, Nian-Yun ^{[2
]}

Tian, Hong-Lei ^{[1
]}

Qiao, Chun-Feng ^{[2
]}

Song, Jing-Zheng ^{[2
]}

Chang, Donald C. ^{[3
]}

Chen, Shi-Lin ^{[4
]}

Luo, Kathy Q. ^{[1
]}

Xu, Hong-Xi ^{[2
]}

机构：

[1] Hong Kong Univ Sci & Technol, Bioengn Grad Program, Dept Chem Engn, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China

[4] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 11期

关键词：

Garcinia xipshuanbannaensis; Clusiaceae; xanthone; growth inhibition; HeLa cells; bannaxanthones;

D O I：

10.1016/j.phytochem.2008.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2187 / 2192

页数：6

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