Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases

被引：11

作者：

Fazio, Antonietta ^{[1
]}

Obeng, Eric Owusu ^{[1
]}

Rusciano, Isabella ^{[1
]}

Marvi, Maria Vittoria ^{[1
]}

Zoli, Matteo ^{[2
,3
]}

Mongiorgi, Sara ^{[1
]}

Ramazzotti, Giulia ^{[1
]}

Follo, Matilde Yung ^{[1
]}

McCubrey, James A. ^{[4
]}

Cocco, Lucio ^{[1
]}

Manzoli, Lucia ^{[1
]}

Ratti, Stefano ^{[1
]}

机构：

[1] Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Cellular Signalling Lab, Via Irnerio 48, I-40126 Bologna, Italy

[2] IRCCS, Ctr Diag & Treatment Hypothalam Pituitary Dis, Pituitary Unit, Ist Sci Neurol Bologna, I-40126 Bologna, Italy

[3] Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, I-40126 Bologna, Italy

[4] East Carolina Univ, Dept Microbiol & Immunol, Brody Sch Med, Greenville, NC 27858 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 15期

关键词：

diacylglycerol; phosphoinositide; PI3K; Akt; mTOR; DGKs; lipids; cancer; ANCHORAGE-INDEPENDENT GROWTH; PROTEIN-KINASE; PHOSPHATIDIC-ACID; NUCLEAR-LOCALIZATION; ALPHA; ACTIVATION; ZETA; CELLS; IDENTIFICATION; EXPRESSION;

D O I：

10.3390/ijms21155297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGK alpha, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA.

引用

页码：1 / 19

页数：19

共 125 条

[1]

Abramovici H, 2003, MOL BIOL CELL, V14, P4499, DOI 10.1091/mbc.e03-03-0190

[2] Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI [J].