C-Type Lectins in Veterinary Species: Recent Advancements and Applications

被引：18
作者：
Lindenwald, Dimitri Leonid
Lepenies, Bernd [1 ]
机构：
[1] Univ Vet Med Hannover, Immunol Unit, D-30559 Hannover, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 14期
关键词：
C-type lectin; glycans; immune modulation; comparative immunology; veterinary immunology; BETA-GLUCAN RECOGNITION; DENDRITIC CELLS; PATHOGEN RECOGNITION; DC-SIGN; RECEPTOR; EXPRESSION; INNATE; DECTIN-1; MINCLE; IDENTIFICATION;
D O I：
10.3390/ijms21145122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
C-type lectins (CTLs), a superfamily of glycan-binding receptors, play a pivotal role in the host defense against pathogens and the maintenance of immune homeostasis of higher animals and humans. CTLs in innate immunity serve as pattern recognition receptors and often bind to glycan structures in damage- and pathogen-associated molecular patterns. While CTLs are found throughout the whole animal kingdom, their ligand specificities and downstream signaling have mainly been studied in humans and in model organisms such as mice. In this review, recent advancements in CTL research in veterinary species as well as potential applications of CTL targeting in veterinary medicine are outlined.
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页码：1 / 16
页数：16
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共 144 条
[21]   Dectin-1 Compromises Innate Responses and Host Resistance against Neospora caninum Infection [J].
da Silva, Murilo Vieira ;
Ferreira Franca, Flavia Batista ;
Mota, Caroline Martins ;
de Macedo Junior, Arlindo Gomes ;
Pires Ramos, Eliezer Lucas ;
Santiago, Fernanda Maria ;
Mineo, Jose Roberto ;
Patriarca Mineo, Tiago Wilson .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[22]   C-type lectins in immunity: recent developments [J].
Dambuza, Ivy M. ;
Brown, Gordon D. .
CURRENT OPINION IN IMMUNOLOGY, 2015, 32 :21-27
[23]   Rational design of adjuvants targeting the C-type lectin Mincle [J].
Decout, Alexiane ;
Silva-Gomes, Sandro ;
Drocourt, Daniel ;
Barbe, Sophie ;
Andre, Isabelle ;
Cueto, Francisco ;
Lioux, Thierry ;
Sancho, David ;
Perouzel, Eric ;
Vercellone, Alain ;
Prandi, Jacques ;
Gilleron, Martine ;
Tiraby, Gerard ;
Nigou, Jerome .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (10) :2675-2680
[24]   DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment [J].
del Fresno, Carlos ;
Saz-Leal, Paula ;
Enamorado, Michel ;
Wculek, Stefanie K. ;
Martinez-Cano, Sarai ;
Blanco-Menendez, Noelia ;
Schulz, Oliver ;
Gallizioli, Mattia ;
Miro-Mur, Francesc ;
Cano, Eva ;
Planas, Anna ;
Sancho, David .
SCIENCE, 2018, 362 (6412) :351-+
[25]   Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation [J].
del Fresno, Carlos ;
Iborra, Salvador ;
Saz-Leal, Paula ;
Martinez-Lopez, Maria ;
Sancho, David .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[26]   C-type lectins facilitate tumor metastasis [J].
Ding, Dongbing ;
Yao, Yao ;
Zhang, Songbai ;
Su, Chunjie ;
Zhang, Yonglian .
ONCOLOGY LETTERS, 2017, 13 (01) :13-21
[27]   Recent insights into structures and functions of C-type lectins in the immune system [J].
Drickamer, Kurt ;
Taylor, Maureen E. .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2015, 34 :26-34
[28]   Mechanistic Insights into the Role of C-Type Lectin Receptor/CARD9 Signaling in Human Antifungal Immunity [J].
Drummond, Rebecca A. ;
Lionakis, Michail S. .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2016, 6
[29]   Mechanism of pathogen recognition by human dectin-2 [J].
Feinberg, Hadar ;
Jegouzo, Sabine A. F. ;
Rex, Maximus J. ;
Drickamer, Kurt ;
Weis, William I. ;
Taylor, Maureen E. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (32) :13402-13414
[30]   Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis [J].
Garcia-Vallejo, Juan J. ;
van Kooyk, Yvette .
IMMUNOLOGICAL REVIEWS, 2009, 230 :22-37
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