Helicobacter pyloriinfection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

被引：19

作者：

Aydemir, Selim ^{[1
]}

Boyacioglu, Sedat ^{[2
]}

Gur, Gurden ^{[2
]}

Demirbilek, Muge ^{[3
]}

Can, Fusun Kamber ^{[3
]}

Korkmaz, Murat ^{[2
]}

Yilmaz, Ugur ^{[2
]}

机构：

[1] Zonguldak Karaelmas Univ Fac Med, Dept Gastroenterol, TR-67800 Zonguldak, Turkey

[2] Baskent Univ Fac Med, Dept Gastroenterol, TR-06000 Ankara, Turkey

[3] Baskent Univ Fac Med, Dept Clin Microbiol, TR-06000 Ankara, Turkey

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 06期

关键词：

Helicobacter pylori; Chronic renal failure; Antibiotic resistance; Clarithromycin; Amoxicillin;

D O I：

10.3748/wjg.v11.i6.842

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age-and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05). CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：842 / 845

页数：4

共 36 条

[1] Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin -: Influence on treatment outcome [J].

Adamek, RJ ;

Suerbaum, S ;

Pfaffenbach, B ;

Opferkuch, W .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1998, 93 (03) :386-389

[2] Antibiotic resistance problems with Helicobacter pylori [J].

Alarcón, T ;

Domingo, D ;

López-Brea, M .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1999, 12 (01) :19-26

[3]

[Anonymous], AM J MED

[4] Treatment of Helicobacter pylori infection.: Indications and regimens:: an update [J].

Bazzoli, F ;

Porro, GB ;

Maconi, G ;

Molteni, M ;

Pozzato, P ;

Zagari, RM .

DIGESTIVE AND LIVER DISEASE, 2002, 34 (01) :70-83

[5] The status of antimicrobial resistance of Helicobacter pylori in eastern Europe [J].

Boyanova, L ;

Mentis, A ;

Gubina, M ;

Rozynek, E ;

Gosciniak, G ;

Kalenic, S ;

Göral, V ;

Kupcinskas, L ;

Kantarçeken, B ;

Aydin, A ;

Archimandritis, A ;

Dzierzanowska, D ;

Vcev, A ;

Ivanova, K ;

Marina, M ;

Mitov, I ;

Petrov, P ;

Özden, A ;

Popova, M .

CLINICAL MICROBIOLOGY AND INFECTION, 2002, 8 (07) :388-396

[6]

Ellenrieder V, 1999, SCAND J GASTROENTERO, V34, P750, DOI 10.1080/003655299750025660

[7] Helicobacter pylori infection in patients with end-stage renal disease [J].

Fabrizi, F ;

Martin, P .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2000, 23 (03) :157-164

[8] Factors affecting the variation in antibiotic resistance of Helicobacter pylori over a 3-year period [J].

Ferrero, M ;

Ducóns, JA ;

Sicilia, B ;

Santolaria, S ;

Sierra, E ;

Gomollón, F .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (03) :245-248

[9] European Multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori [J].

Glupczynski, Y ;

Mégraud, F ;

Lopez-Brea, M ;

Andersen, LP .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2001, 20 (11) :820-823

[10] ERADICATION OF HELICOBACTER-PYLORI [J].

HARRIS, AW ;

MISIEWICZ, JJ .

BAILLIERES CLINICAL GASTROENTEROLOGY, 1995, 9 (03) :583-613

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