Platelets and matrix metalloproteinases

被引：65

作者：

Seizer, Peter ^{[1
]}

May, Andreas E. ^{[1
]}

机构：

[1] Univ Tubingen, Med Klin 3, Tubingen, Germany

来源：

THROMBOSIS AND HAEMOSTASIS | 2013年 / 110卷 / 05期

关键词：

Platelets; MMP; EMMPRIN; ACUTE CORONARY SYNDROMES; HUMAN ENDOTHELIAL-CELLS; MONOCYTE INTERACTIONS; TARGETED DELETION; MYOCARDIAL-INFARCTION; LIGAND CYCLOPHILIN; TISSUE INHIBITOR; T-LYMPHOCYTES; IN-VITRO; EXPRESSION;

D O I：

10.1160/TH13-02-0113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Matrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes. First, platelets can concentrate leukocyte-derived MMP activity to sites of vascular injury by leukocyte recruitment. Second, platelets stimulate MMP production in e.g. leukocytes, endothelial cells, or tumour cells by direct receptor interaction or/and by paracrine pathways. Third, platelets synthesise and secrete a variety of MMPs including M MP-1, MMP-2, MMP-3, and MMP-14 (MT1-MMP), and potentially MMP-9 as well as the tissue inhibitors of metalloproteinase (TIMPs). This review focuses on platelet-derived and platelet-induced MMPs and their inhibitors.

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收藏

页码：903 / 909

页数：7

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