A Convergent Total Synthesis of the Potent Cephalostatin/Ritterazine Hybrid-25-epi Ritterostatin GN1N

被引：9

作者：

Kanduluru, Ananda Kumar ^{[1
]}

Banerjee, Prabal ^{[1
]}

Beutler, John A. ^{[2
]}

Fuchs, Philip L. ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 18期

关键词：

EFFICIENT PROTOCOL; HECOGENIN ACETATE; HEMISPHERE; SUPPORT; UNIT; FUNCTIONALIZATION; CEPHALOSTATIN-1;

D O I：

10.1021/jo401171q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The convergent synthesis of 25-epi ritterostatin G(N)1(N) is described for the first time, starting from hecogenin acetate (HA). Stereoselective dihydroxylation employing the chiral ligand (DHQ)(2)PHAL was used as the key step to introduce the C25 epi-stereocenter on the north 1 segment. The title compound was obtained through a coupling reaction between the C3-keto-azide (cstat North 1) and North G.

引用

页码：9085 / 9092

页数：8

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