Systems approaches to studying the immune response in tuberculosis

被引：28

作者：

Berry, Matthew Paul Reddoch ^{[1
,2
]}

Blankley, Simon ^{[1
]}

Graham, Christine Marian ^{[1
]}

Bloom, Chloe I. ^{[1
]}

O'Garra, Anne ^{[1
,3
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept Resp Med, London W2 1NY, England

[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, NHLI, London SW7 2AZ, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 05期

基金：

英国医学研究理事会;

关键词：

GENE-EXPRESSION PROFILES; HUMAN DENDRITIC CELLS; MYCOBACTERIUM-TUBERCULOSIS; INDOLEAMINE 2,3-DIOXYGENASE; LATENT TUBERCULOSIS; HUMAN MACROPHAGES; PULMONARY; MICROARRAY; SIGNATURE; INFECTION;

D O I：

10.1016/j.coi.2013.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) remains a disease of considerable mortality and morbidity. Studies employing microarrays to derive transcriptional profiles of the host response during TB, which combined with data from experimental systems have highlighted a potentially detrimental role for type I interferons during infection, with important implications for vaccine and therapeutic development. In addition, these studies have provided candidate biomarkers which may advance diagnosis and treatment monitoring. These studies thus exemplify the promise of a systems biology approach to study complex infectious disease such as TB.

引用

页码：579 / 587

页数：9

共 58 条

[1] Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum [J].

Agranoff, Dan ;

Fernandez-Reyes, Delmiro ;

Papadopoulos, Marios C. ;

Rojas, Sergio A. ;

Herbster, Mark ;

Loosemore, Alison ;

Tarelli, Edward ;

Sheldon, Jo ;

Schwenk, Achim ;

Pollak, Richard ;

Rayner, Charlotte F. J. ;

Krishna, Sarjeev .

LANCET, 2006, 368 (9540) :1012-1021

[2]

[Anonymous], 2013, LANCET

[3] The spectrum of latent tuberculosis: rethinking the biology and intervention strategies [J].

Barry, Clifton E., III ;

Boshoff, Helena I. ;

Dartois, Veronique ;

Dick, Thomas ;

Ehrt, Sabine ;

Flynn, JoAnne ;

Schnappinger, Dirk ;

Wilkinson, Robert J. ;

Young, Douglas .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (12) :845-855

[4] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis [J].

Berry, Matthew P. R. ;

Graham, Christine M. ;

McNab, Finlay W. ;

Xu, Zhaohui ;

Bloch, Susannah A. A. ;

Oni, Tolu ;

Wilkinson, Katalin A. ;

Banchereau, Romain ;

Skinner, Jason ;

Wilkinson, Robert J. ;

Quinn, Charles ;

Blankenship, Derek ;

Dhawan, Ranju ;

Cush, John J. ;

Mejias, Asuncion ;

Ramilo, Octavio ;

Kon, Onn M. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

O'Garra, Anne .

NATURE, 2010, 466 (7309) :973-U98

[5] Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers [J].

Bloom, Chloe I. ;

Graham, Christine M. ;

Berry, Matthew P. R. ;

Rozakeas, Fotini ;

Redford, Paul S. ;

Wang, Yuanyuan ;

Xu, Zhaohui ;

Wilkinson, Katalin A. ;

Wilkinson, Robert J. ;

Kendrick, Yvonne ;

Devouassoux, Gilles ;

Ferry, Tristan ;

Miyara, Makoto ;

Bouvry, Diane ;

Dominique, Valeyre ;

Gorochov, Guy ;

Blankenship, Derek ;

Saadatian, Mitra ;

Vanhems, Phillip ;

Beynon, Huw ;

Vancheeswaran, Rama ;

Wickremasinghe, Melissa ;

Chaussabel, Damien ;

Banchereau, Jacques ;

Pascual, Virginia ;

Ho, Ling-pei ;

Lipman, Marc ;

O'Garra, Anne .

PLOS ONE, 2013, 8 (08)

[6] Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis Therapy [J].

Bloom, Chloe I. ;

Graham, Christine M. ;

Berry, Matthew P. R. ;

Wilkinson, Katalin A. ;

Oni, Tolu ;

Rozakeas, Fotini ;

Xu, Zhaohui ;

Rossello-Urgell, Jose ;

Chaussabel, Damien ;

Banchereau, Jacques ;

Pascual, Virginia ;

Lipman, Marc ;

Wilkinson, Robert J. ;

O'Garra, Anne .

PLOS ONE, 2012, 7 (10)

[7] Alpha/beta interferon impairs the ability of human macrophages to control growth of Mycobacterium bovis BCG [J].

Bouchonnet, F ;

Boechat, N ;

Bonay, M ;

Hance, AJ .

INFECTION AND IMMUNITY, 2002, 70 (06) :3020-3025

[8] The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis [J].

Caws, Maxine ;

Thwaites, Guy ;

Dunstan, Sarah ;

Hawn, Thomas R. ;

Lan, Nguyen Thi Ngoc ;

Thuong, Nguyen Thuy Thuong ;

Stepniewska, Kasia ;

Huyen, Mai Nguyet Thu ;

Bang, Nguyen Duc ;

Loc, Tran Huu ;

Gagneux, Sebastien ;

van Soolingen, Dick ;

Kremer, Kristin ;

van der Sande, Marianne ;

Small, Peter ;

Anh, Phan Thi Hoang ;

Chinh, Nguyen Tran ;

Quy, Hoang Thi ;

Duyen, Nguyen Thi Hong ;

Tho, Dau Quang ;

Hieu, Nguyen T. ;

Torok, Estee ;

Hien, Tran Tinh ;

Dung, Nguyen Huy ;

Nhu, Nguyen Thi Quynh ;

Duy, Phan Minh ;

Chau, Nguyen van Vinh ;

Farrar, Jeremy .

PLOS PATHOGENS, 2008, 4 (03)

[9] Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites [J].

Chaussabel, D ;

Semnani, RT ;

McDowell, MA ;

Sacks, D ;

Sher, A ;

Nutman, TB .

BLOOD, 2003, 102 (02) :672-681

[10] Assessing the human immune system through blood transcriptomics [J].

Chaussabel, Damien ;

Pascual, Virginia ;

Banchereau, Jacques .

BMC BIOLOGY, 2010, 8

← 1 2 3 4 5 6 →