Potential role of taurine in the prevention of diabetes and metabolic syndrome

被引：65

作者：

Imae, Masato ^{[1
]}

Asano, Toshiki ^{[1
]}

Murakami, Shigeru ^{[2
]}

机构：

[1] Taisho Pharmaceut Co Ltd, R&D Labs, Self Medicat Business, Kita Ku, Saitama 3319530, Japan

[2] Taisho Pharmaceut Co Ltd, R&D Headquarters, Self Medicat Business, Toshima Ku, Tokyo 1708633, Japan

来源：

AMINO ACIDS | 2014年 / 46卷 / 01期

关键词：

Taurine; Diabetes; Metabolic syndrome; SPONTANEOUSLY HYPERTENSIVE-RATS; HIGH-CHOLESTEROL DIET; SYMPATHETIC-NERVE ACTIVITY; INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS; ALVEOLAR MACROPHAGES; NUTRITIONAL FACTOR; N-ACETYLCYSTEINE; PLATELET TAURINE; ANGIOTENSIN-II;

D O I：

10.1007/s00726-012-1434-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic syndrome is characterized by the cluster of a number of metabolic abnormalities in the presence of underlying insulin resistance. The prevalence of metabolic syndrome has steadily increased in all populations worldwide. Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid that is involved in a variety of physiological functions. Clinical and experimental studies show that taurine intake may be beneficial in the prevention of metabolic syndrome including diabetes, obesity, dyslipidemia, and hypertension. This article reviews the effect of taurine on all of the components of metabolic syndrome. In addition, the possible mechanisms by which taurine prevents diabetes and metabolic syndrome are also discussed. Further study is needed to determine the role of taurine in the development of metabolic syndrome in humans, because there is presently limited clinical data available.

引用

页码：81 / 88

页数：8

共 84 条

[1] Effects of chronic taurine treatment on reactivity of the rat aorta [J].

Abebe, W ;

Mozaffari, MS .

AMINO ACIDS, 2000, 19 (3-4) :615-623

[2] Taurine attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac myocytes [J].

Azuma, M ;

Takahashi, K ;

Fukuda, T ;

Ohyabu, Y ;

Yamamoto, I ;

Kim, S ;

Iwao, H ;

Schaffer, SW ;

Azuma, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 403 (03) :181-188

[3] Taurine chloramine inhibits inducible nitric oxide synthase and TNF-α gene expression in activated alveolar macrophages:: Decreased NF-κB activation and IκB kinase activity [J].

Barua, M ;

Liu, Y ;

Quinn, MR .

JOURNAL OF IMMUNOLOGY, 2001, 167 (04) :2275-2281

[4] Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus [J].

Brons, C ;

Spohr, C ;

Storgaard, H ;

Dyerberg, J ;

Vaag, A .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2004, 58 (09) :1239-1247

[5] Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[6] Taurine supplementation modulates glucose homeostasis and islet fanction [J].

Carneiro, Everardo A. ;

Latorraca, Marcia Q. ;

Araujo, Eliana ;

Beltra, Marta ;

Oliveras, Maria J. ;

Navarro, Monica ;

Berna, Genoveva ;

Bedoya, Francisco J. ;

Velloso, Licio A. ;

Soria, Bernat ;

Martin, Franz .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2009, 20 (07) :503-511

[7]

Chang KJ, 2000, ADV EXP MED BIOL, V483, P579

[8]

Chauncey KB, 2003, ADV EXP MED BIOL, V526, P91

[9] The restorative effect of taurine on experimental nonalcoholic steatohepatitis [J].

Chen, Si-Wen ;

Chen, Yue-Xiang ;

Shi, Jian ;

Lin, Yong ;

Xie, Wei-Fen .

DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (12) :2225-2234

[10] The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet [J].

Chen, W ;

Matuda, K ;

Nishimura, N ;

Yokogoshi, H .

LIFE SCIENCES, 2004, 74 (15) :1889-1898

← 1 2 3 4 5 6 7 8 9 →