The immune environment of paediatric solid malignancies: evidence from an immunohistochemical study of clinical cases

被引：16

作者：

Apps, John R. ^{[1
]}

Hasan, Fyeza ^{[1
]}

Campus, Oliver ^{[2
]}

Behjati, Sam ^{[1
]}

Jacques, Thomas S. ^{[2
]}

Sebire, Neil J. ^{[2
]}

Anderson, John ^{[3
]}

机构：

[1] UCL Inst Child Hlth, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, London, England

[3] UCL Inst Child Hlth, Unit Mol Haematol & Canc Biol, London WC1N 1EH, England

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2013年 / 32卷 / 04期

关键词：

CD3; CD68; immune environment; paediatric cancer; STAT3; CELLS; CANCER; INHIBITION;

D O I：

10.3109/15513815.2012.754527

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Childhood malignancies are relatively poorly studied in terms of tumour/host interaction. Using tissue arrays of childhood cancers, we analysed immunohistochemical staining for CD68, CD3 and FOXP3 to evaluate infiltration of myeloid cells, lymphocytes and regulatory T cells. Staining for phosphorylated STAT3 was performed in a subset. The majority of paediatric tumours demonstrated a marked infiltration of CD68+ myeloid cells but, with the exception of neuroblastoma, most showed only sparse infiltration of CD3+/FOXP3-cells. There was evidence for activation of STAT3 in pPNET (50%), ependymoma (45%) and undifferentiated sarcoma (38%), but it was rarely activated in other tumours.

引用

页码：298 / 307

页数：10

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[21] Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages [J].