MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors

被引：24

作者：

Jin, Ai-Hua

Vetter, Irina

Dutertre, Sebastien

Abraham, Nikita

Emidio, Nayara B.

Inserra, Marco

Murali, Swetha S.

Christie, MacDonald J.

Alewood, Paul F.

Lewis, Richard J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

BIOCHEMISTRY | 2014年 / 53卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

CONE SNAIL VENOM; BINDING; PEPTIDES;

D O I：

10.1021/bi400882s

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Their high selectivity and affinity for the various subtypes of nAChRs have led to significant advances in our understanding of the structure and function of these key ion channels. Here we report the discovery of a novel 4/7 alpha-conotoxin, MrIC from the venom duct of Conus marmoreus, which acts as an agonist at the endogenous human alpha 7 nAChR in SH-SY5Y cells pretreated with PNU120596 (PNU). This unique agonist activity of MrIC at alpha 7 nAChRs may guide the development of novel alpha 7 nAChR modulators.

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页码：1 / 3

页数：3

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