Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment

被引：28
作者：
Ruan, Yongsheng [1 ,2 ]
Kim, Hye Na [1 ]
Ogana, Heather [1 ]
Kim, Yong-Mi [1 ]
机构：
[1] Univ Southern Calif, Childrens Hosp Los Angeles, Norris Comprehens Canc Ctr, Dept Pediat,Div Hematol Oncol Blood & Marrow Tran, Los Angeles, CA 90027 USA
[2] Southern Med Univ, Nanfang Hosp, Dept Pediat, Guangzhou 510515, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 17期
关键词：
Wnt signaling; leukemia; leukemia stem cell; leukemia microenvironment; ACUTE LYMPHOBLASTIC-LEUKEMIA; MESENCHYMAL STROMAL CELLS; HEALTH-ORGANIZATION CLASSIFICATION; TYROSINE KINASE INHIBITORS; WNT/BETA-CATENIN PATHWAY; HEMATOPOIETIC STEM-CELLS; BETA-CATENIN; CANONICAL WNT; THERAPEUTIC TARGET; MYELOID NEOPLASMS;
D O I：
10.3390/ijms21176247
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and osteoblasts. Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role of Wnt signaling in leukemia and its microenvironment and provide information on the currently available strategies for targeting Wnt signaling.
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页码：1 / 20
页数：20
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