Sex Dependence of Cognitive Functions in Bipolar Disorder

被引:17
作者
Suwalska, Aleksandra [1 ]
Lojko, Dorota [1 ]
机构
[1] Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland
关键词
SPATIAL WORKING-MEMORY; GENDER-DIFFERENCES; EUTHYMIC PATIENTS; 1ST-DEGREE RELATIVES; BRAIN STRUCTURE; RATING-SCALE; GRAY-MATTER; SCHIZOPHRENIA; METAANALYSIS; IMPAIRMENT;
D O I
10.1155/2014/418432
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls in the spatial memory and planning as well as verbal fluency tests. We detected a gender-related imbalance in the SWM results. Deficits in SWM were observed in male-only comparisons but not in female-only comparisons. The SWM scores were significantly poorer in male patients than in male controls. In female-only comparisons, female patients did not have significantly poorer SWM results in any category than their controls. Bipolar women scored worse in some other tests. The present study points to the different patterns of neuropsychological disturbances in female and male patients and suggests that sex-dependent differences should be taken into account in order to tailor the therapeutic intervention aimed at the improvement of cognitive functions.
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页数:10
相关论文
共 84 条
[1]   Sex influences on the neurobiology of learning and memory [J].
Andreano, Joseph M. ;
Cahill, Larry .
LEARNING & MEMORY, 2009, 16 (04) :248-266
[2]  
[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787
[3]   Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives [J].
Arts, B. ;
Jabben, N. ;
Krabbendam, L. ;
van Os, J. .
PSYCHOLOGICAL MEDICINE, 2008, 38 (06) :771-785
[4]   Neurocognition in bipolar disorders-A closer look at comorbidities and medications [J].
Balanza-Martinez, Vicent ;
Selva, Gabriel ;
Martinez-Aran, Anabel ;
Prickaerts, Jos ;
Salazar, Jose ;
Gonzalez-Pinto, Ana ;
Vieta, Eduard ;
Tabares-Seisdedos, Rafael .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 626 (01) :87-96
[5]   Gender influences the detection of spatial working memory deficits in bipolar disorder [J].
Barrett, Suzanne Lucia ;
Kelly, Christopher ;
Bell, Robert ;
King, David John .
BIPOLAR DISORDERS, 2008, 10 (05) :647-654
[6]   The effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patients [J].
Bora, Emre ;
Vahip, Simavi ;
Akdeniz, Fisun ;
Gonul, Ali Saffet ;
Eryavuz, Ayse ;
Ogut, Melise ;
Alkan, Muge .
BIPOLAR DISORDERS, 2007, 9 (05) :468-477
[7]   Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives [J].
Bora, Emre ;
Yucel, Murat ;
Pantelis, Christos .
JOURNAL OF AFFECTIVE DISORDERS, 2009, 113 (1-2) :1-20
[8]   WORD FLUENCY AND BRAIN DAMAGE [J].
BORKOWSKI, JG ;
BENTON, AL ;
SPREEN, O .
NEUROPSYCHOLOGIA, 1967, 5 (02) :135-+
[9]   Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis [J].
Bourne, C. ;
Aydemir, O. ;
Balanza-Martinez, V. ;
Bora, E. ;
Brissos, S. ;
Cavanagh, J. T. O. ;
Clark, L. ;
Cubukcuoglu, Z. ;
Dias, V. V. ;
Dittmann, S. ;
Ferrier, I. N. ;
Fleck, D. E. ;
Frangou, S. ;
Gallagher, P. ;
Jones, L. ;
Kieseppa, T. ;
Martinez-Aran, A. ;
Melle, I. ;
Moore, P. B. ;
Mur, M. ;
Pfennig, A. ;
Raust, A. ;
Senturk, V. ;
Simonsen, C. ;
Smith, D. J. ;
Bio, D. S. ;
Soeiro-de-Souza, M. G. ;
Stoddart, S. D. R. ;
Sundet, K. ;
Szoke, A. ;
Thompson, J. M. ;
Torrent, C. ;
Zalla, T. ;
Craddock, N. ;
Andreassen, O. A. ;
Leboyer, M. ;
Vieta, E. ;
Bauer, M. ;
Worhunsky, P. D. ;
Tzagarakis, C. ;
Rogers, R. D. ;
Geddes, J. R. ;
Goodwin, G. M. .
ACTA PSYCHIATRICA SCANDINAVICA, 2013, 128 (03) :149-162
[10]  
Bowden Charles, 2006, Neuropsychiatr Dis Treat, V2, P149, DOI 10.2147/nedt.2006.2.2.149