The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer

被引：16

作者：

Birkeland, Andrew C. ^{[1
]}

Ludwig, Megan L. ^{[1
]}

Meraj, Taha S. ^{[1
]}

Brenner, J. Chad ^{[1
,2
]}

Prince, Mark E. ^{[1
,2
]}

机构：

[1] Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan Hlth Syst, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

CANCERS | 2015年 / 7卷 / 04期

关键词：

HNSCC; targeted therapy; TCGA; genomic; cancer; precision medicine; personalized medicine; SQUAMOUS-CELL CARCINOMA; PLUS CETUXIMAB; LANDSCAPE; SURVIVAL; HETEROGENEITY; INHIBITION; MUTATIONS; HPV; IDENTIFICATION; BIOMARKERS;

D O I：

10.3390/cancers7040879

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent genomic sequencing studies have provided valuable insight into genetic aberrations in head and neck squamous cell carcinoma. Despite these great advances, certain hurdles exist in translating genomic findings to clinical care. Further correlation of genetic findings to clinical outcomes, additional analyses of subgroups of head and neck cancers and follow-up investigation into genetic heterogeneity are needed. While the development of targeted therapy trials is of key importance, numerous challenges exist in establishing and optimizing such programs. This review discusses potential upcoming steps for further genetic evaluation of head and neck cancers and implementation of genetic findings into precision medicine trials.

引用

页码：2094 / 2109

页数：16

共 55 条

[1] Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[2] Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability [J].

Akagi, Keiko ;

Li, Jingfeng ;

Broutian, Tatevik R. ;

Padilla-Nash, Hesed ;

Xiao, Weihong ;

Jiang, Bo ;

Rocco, James W. ;

Teknos, Theodoros N. ;

Kumar, Bhavna ;

Wangsa, Danny ;

He, Dandan ;

Ried, Thomas ;

Symer, David E. ;

Gillison, Maura L. .

GENOME RESEARCH, 2014, 24 (02) :185-199

[3]

Ang KK, 2002, CANCER RES, V62, P7350

[4] NCI Prepares to Launch MATCH Trial [J].

不详 .

CANCER DISCOVERY, 2015, 5 (07) :685-685

[5] Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response [J].

Beltran, Himisha ;

Eng, Kenneth ;

Mosquera, Juan Miguel ;

Sigaras, Alexandros ;

Romanel, Alessandro ;

Rennert, Hanna ;

Kossai, Myriam ;

Pauli, Chantal ;

Faltas, Bishoy ;

Fontugne, Jacqueline ;

Park, Kyung ;

Banfelder, Jason ;

Prandi, Davide ;

Madhukar, Neel ;

Zhang, Tuo ;

Padilla, Jessica ;

Greco, Noah ;

McNary, Terra J. ;

Herrscher, Erick ;

Wilkes, David ;

MacDonald, Theresa Y. ;

Xue, Hui ;

Vacic, Vladimir ;

Emde, Anne-Katrin ;

Oschwald, Dayna ;

Tan, Adrian Y. ;

Chen, Zhengming ;

Collins, Colin ;

Gleave, Martin E. ;

Wang, Yuzhuo ;

Chakravarty, Dimple ;

Schiffman, Marc ;

Kim, Robert ;

Campagne, Fabien ;

Robinson, Brian D. ;

Nanus, David M. ;

Tagawa, Scott T. ;

Xiang, Jenny Z. ;

Smogorzewska, Agata ;

Demichelis, Francesca ;

Rickman, David S. ;

Sboner, Andrea ;

Elemento, Olivier ;

Rubin, Mark A. .

JAMA ONCOLOGY, 2015, 1 (04) :466-474

[6]

Birkeland A. C., 2015, IDENTIFICATION UNPUB

[7] Getting personal: Head and neck cancer management in the era of genomic medicine [J].

Birkeland, Andrew C. ;

Uhlmann, Wendy R. ;

Brenner, J. Chad ;

Shuman, Andrew G. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 :E2250-E2258

[8] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[9] Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group [J].

Bookman, MA ;

Darcy, KM ;

Clarke-Pearson, D ;

Boothby, RA ;

Horowitz, IR .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (02) :283-290

[10] Biomarkers in Advanced Larynx Cancer [J].

Bradford, Carol R. ;

Kumar, Bhavna ;

Bellile, Emily ;

Lee, Julia ;

Taylor, Jeremy ;

D'Silva, Nisha ;

Cordell, Kitrina ;

Kleer, Celina ;

Kupfer, Robbi ;

Kumar, Pawan ;

Urba, Susan ;

Worden, Francis ;

Eisbruch, Avraham ;

Wolf, Gregory T. ;

Teknos, Theodoros N. ;

Prince, Mark E. P. ;

Chepeha, Douglas B. ;

Hogikyan, Norman D. ;

Moyer, Jeffrey S. ;

Carey, Thomas E. .

LARYNGOSCOPE, 2014, 124 (01) :179-187

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