Pneumonitis Induced by Rifampicin: A Case Report and Literature Review

被引：2

作者：

Koma, Yasuko ^{[1
]}

Goto, Keiko ^{[1
]}

Yoshida, Chihiro ^{[1
]}

Kimura, Kengo ^{[1
]}

Matsumoto, Yusuke ^{[1
]}

Koyama, Midori ^{[1
]}

Nakashima, Nariyasu ^{[1
]}

Masuya, Daiki ^{[1
]}

Matsuoka, Hirofumi ^{[1
]}

Yoshimatsu, Harukazu ^{[1
]}

Suzuki, Yujiro ^{[1
]}

机构：

[1] Shinko Hosp, Resp Ctr, Kobe, Hyogo, Japan

来源：

INTERNAL MEDICINE | 2013年 / 52卷 / 04期

关键词：

rifampicin; miliary tuberculosis; drug-induced pneumonitis; corticosteroid; bronchoalveolar lavage fluid; LYMPHOCYTE STIMULATION TEST; PULMONARY TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; PERIPHERAL-BLOOD; PREDNISOLONE; FLUID;

D O I：

10.2169/internalmedicine.52.8997

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 84-year-old woman being treated for miliary tuberculosis (TB) with rifampicin (RFP), isoniazid (INH), ethambutol (EB) and corticosteroids suffered from a persistent fever for five months. While tapering the dose of prednisolone, chest computed tomography (CT) revealed diffuse ground glass opacities (GGO) and bronchoalveolar lavage fluid (BALF) showed an increase in lymphocytes. After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. However, readministration of RFP provoked an inflammatory reaction, leading to a diagnosis of RFP-induced pneumonitis. This condition is very rare. This is the first report of RFP-induced pneumonitis occurring during adjunct steroid therapy.

引用

页码：473 / 477

页数：5

共 17 条

[1] Drug-induced pneumonitis: Thin-section CT findings in 60 patients [J].