COPPER-CATALYZED β-IODOVINYLATION OF AZOLE AND PYRROLE DERIVATIVES

被引：1

作者：

Ricard, Simon ^{[1
]}

Ladouceur, Francois ^{[1
]}

Couture, Guillaume ^{[1
]}

Daoust, Benoit ^{[1
]}

机构：

[1] Univ Quebec Trois Rivieres, Dept Chem Biochem & Phys, CP 500, Trois Rivieres, PQ G9A 5H7, Canada

来源：

HETEROCYCLES | 2020年 / 100卷 / 05期

关键词：

N-ARYLATION; REGIOSELECTIVE SYNTHESIS; ARYL; EFFICIENT; MILD; VINYLATION; PALLADIUM; INDOLES; WATER; ACCESS;

D O I：

10.3987/COM-20-14234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein is described an efficient copper-catalyzed synthesis of beta-iodovinyl-azole and beta-iodovinyl-pyrrole derivatives using (E)-1,2-diiodoethene which was efficiently applied to azole and pyrrole derivatives in both organic and hydro-organic medium to afford the corresponding beta-iodovinylated adducts in up to excellent yields with complete stereocontrol. These nitrogenated vinyl iodides can be further functionalized into disubstituted olefins through various metal catalyzed coupling reactions.

引用

页码：747 / 767

页数：21

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