The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

被引：59

作者：

Ding, Mei ^{[1
]}

Shen, Kang ^{[2
]}

机构：

[1] Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China

[2] Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA

来源：

BIOESSAYS | 2008年 / 30卷 / 11-12期

关键词：

D O I：

10.1002/bies.20843

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS-associated proteins, suggesting the UPS dysfunction may be crucial for pathogenesis. Recent experiments have highlighted the UPS as a key player during synaptic development. Here we summarize recent discoveries centered on the role of the UPS in synapse remodeling and draw attention to the potential link between the synaptic UPS dysfunction and the pathology of neurodegenerative diseases. BioEssays 30:10751083, 2008. (C) 2008 Wiley Periodicals, Inc.

引用

页码：1075 / 1083

页数：9

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