Phase transfer alkylation of arylacetonitriles revisited

被引：28

作者：

Barbasiewicz, Michal ^{[1
]}

Marciniak, Karolina ^{[1
]}

Fedorynski, Michal ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 23期

关键词：

phase transfer catalysis; alkylation; cyclopropanes; cyclobutanes; concentration effect;

D O I：

10.1016/j.tetlet.2006.03.176

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phase transfer alkylations of phenylacetonitrile derivatives carried out in the presence of 60-75% aqueous KOH, instead of the typical 50% NaOH, provide substantial improvements in the overall yields and purity of products. Reactions with simple secondary alkyl halides, as well as cycloalkylations with 1,2- and 1,3-dihaloalkanes proceed with good yields. Increasing the concentration of base diminishes the formation of by-products from competitive beta-elimination processes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3871 / 3874

页数：4

共 34 条

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