Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

被引：174

作者：

Davignon, Jean-Luc ^{[1
,2
,3
,4
]}

Hayder, Myriam ^{[1
,2
,3
]}

Baron, Michel ^{[1
,2
,3
]}

Boyer, Jean-Frederic ^{[1
,2
,3
,4
]}

Constantin, Arnaud ^{[4
,5
]}

Apparailly, Florence ^{[6
,7
]}

Poupot, Remy ^{[1
,2
,3
]}

Cantagrel, Alain ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, U1043, F-31400 Toulouse, France

[2] CNRS, U5282, F-31400 Toulouse, France

[3] Univ Toulouse, UPS, Ctr Physiopathol Toulouse Purpan, F-31400 Toulouse, France

[4] Hop Purpan, Ctr Hosp Univ Toulouse, Ctr Rhumatol, F-31400 Toulouse, France

[5] INSERM, U1027, F-31400 Toulouse, France

[6] Hop St Eloi, INSERM, U844, Montpellier, France

[7] Univ Montpellier I, Montpellier, France

来源：

RHEUMATOLOGY | 2013年 / 52卷 / 04期

关键词：

monocytes; RA; inflammation; novel therapies; biotherapies; targeting; TNF-alpha; siRNA; cPLA(2)alpha; dendrimer; animal models; TUMOR-NECROSIS-FACTOR; COLLAGEN-INDUCED ARTHRITIS; COLONY-STIMULATING FACTORS; TNF-ALPHA; TRANSMEMBRANE TNF; IN-VIVO; C-FMS; CITRULLINATED PROTEINS; MACROPHAGE ACTIVATION; MONOCYTE ACTIVATION;

D O I：

10.1093/rheumatology/kes304

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Biotherapies have revolutionized the treatment of RA. However, much work is needed to understand all the mechanisms of these biotherapies, and alternatives are needed to circumvent adverse effects and the high cost of these long-lasting treatments. In this article we outline some of the approaches we have used to target monocytes/macrophages as major components of inflammation and bone homeostasis. We also discuss how anti-TNF-alpha antibodies target monocytes/macrophages in the complex mechanisms contributing to inhibition of inflammation.

引用

页码：590 / 598

页数：9

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