Matrine: Bioactivities and Structural Modifications

被引：102
作者：
Huang, Jiulin [1 ,2 ]
Xu, Hui [1 ]
机构：
[1] Northwest A&F Univ, Coll Sci, Res Inst Pesticidal Design & Synth, Yangling 712100, Shaanxi Provinc, Peoples R China
[2] Ankang Univ, Sch Chem & Chem Engn, Ankang 725000, Shaanxi Provinc, Peoples R China
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 28期
基金：
中国国家自然科学基金;
关键词：
Matrine derivatives; Biological activities; Structural modifications; Mechanism of action; Structure-activity relationship; Sophora flavescens; HUMAN OSTEOSARCOMA CELLS; NITRIC-OXIDE SYNTHASE; CANCER CELLS; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION; IN-VITRO; BIOLOGICAL EVALUATION; INDUCED APOPTOSIS; DOWN-REGULATION; GROWTH-FACTOR;
D O I：
10.2174/1568026616666160506131012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.
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页码：3365 / 3378
页数：14
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