Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

被引:194
作者
Hermanns, Heike M. [1 ]
机构
[1] Univ Hosp Wurzburg, Dept Internal Med 2, Hepatol Res Lab, D-97080 Wurzburg, Germany
关键词
Oncostatin M; Interleukin-31; Cytokines; Inflammation; Signal transduction; LEUKEMIA INHIBITORY FACTOR; AU-RICH ELEMENTS; IL-31; RECEPTOR; M OSM; T-CELLS; MESSENGER-RNA; M EXPRESSION; FACTOR LIF; HEMATOPOIETIC PROGENITORS; EXTRACELLULAR-MATRIX;
D O I
10.1016/j.cytogfr.2015.07.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMR beta). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:545 / 558
页数:14
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