Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

被引：199

作者：

Hermanns, Heike M. ^{[1
]}

机构：

[1] Univ Hosp Wurzburg, Dept Internal Med 2, Hepatol Res Lab, D-97080 Wurzburg, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 05期

关键词：

Oncostatin M; Interleukin-31; Cytokines; Inflammation; Signal transduction; LEUKEMIA INHIBITORY FACTOR; AU-RICH ELEMENTS; IL-31; RECEPTOR; M OSM; T-CELLS; MESSENGER-RNA; M EXPRESSION; FACTOR LIF; HEMATOPOIETIC PROGENITORS; EXTRACELLULAR-MATRIX;

D O I：

10.1016/j.cytogfr.2015.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMR beta). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：545 / 558

页数：14

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